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dc.contributor.authorDiker, Nurettin
dc.contributor.authorGülsever, Serap
dc.contributor.authorKöroğlu, Taner
dc.contributor.authorYılmaz Akçay, Eda
dc.contributor.authorOğuz, Yener
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:31Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:31Z
dc.date.issued2018en_US
dc.identifier.citationDiker, N., Gülsever, S., Koroğlu, T., Yılmaz Akçay, E. ve Oğuz, Y. (2018). Effects of hyaluronic acid and hydroxyapatite/beta-tricalcium phosphate in combination on bone regeneration of a critical-size defect in an experimental model. Journal of Craniofacial Surgery, 29(4), 1087-1093. https://dx.doi.org/10.1097/SCS.0000000000004338en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.urihttps://dx.doi.org/10.1097/SCS.0000000000004338
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2007
dc.descriptionWOS: 000434304300099en_US
dc.descriptionPubMed ID: 29438204en_US
dc.description.abstractHyaluronic acid (HyA) is an outstanding new product in the field of oral and maxillofacial surgery. The aim of this study was to evaluate the effects of HyA on bone regeneration in critical-size calvarial defects. Twenty-four female Sprague-Dawley rats were used in the present study. In each rat, 4 critical-size defects received different treatments: no treatment (control); HyA; Graft; and HyA+Graft combination. New bone formation, defect closure, inflammation, vascular proliferation, immature bone formation, mature bone formation, and bone marrow existence were investigated based on histological findings. The healing parameters related to bone formation (new bone formation, defect closure, immature bone formation) were significantly higher in the HyA group compared with the control group. However, HyA alone was unable to induce sufficient bone regeneration compared with treatments involving graft materials (Graft and HyA+Graft). In the Graft and HyA+Graft groups, prominent enhancement of all healing parameters was noted. The present results demonstrate that HyA alone did not adequately enhance bone regeneration in critical-size defects. Moreover, addition of HyA to a biphasic alloplastic graft material did not result in improved regeneration compared with the graft material alone.en_US
dc.description.sponsorshipBaskent University Research Funden_US
dc.description.sponsorshipThis research was funded by the Baskent University Research Fund.en_US
dc.language.isoengen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiphasic Bone Graften_US
dc.subjectCalvarial Bone Defecten_US
dc.subjectHyaluronic Aciden_US
dc.titleEffects of hyaluronic acid and hydroxyapatite/beta-tricalcium phosphate in combination on bone regeneration of a critical-size defect in an experimental modelen_US
dc.typearticleen_US
dc.relation.ispartofJournal of Craniofacial Surgeryen_US
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Cerrahisi Ana Bilim Dalıen_US
dc.identifier.volume29en_US
dc.identifier.issue4en_US
dc.identifier.startpage1087en_US
dc.identifier.endpage1093en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1097/SCS.0000000000004338en_US
dc.identifier.wosqualityQ4en_US
dc.identifier.scopusqualityQ2en_US


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