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dc.contributor.authorArslan, Ferhat
dc.contributor.authorAlp, Şehnaz
dc.contributor.authorBüyükaşık, Yahya
dc.contributor.authorCömert Özkan, Melda
dc.contributor.authorŞahin, Fahri
dc.contributor.authorBaşaran, Seniha
dc.contributor.authorÇağatay, Arif Atahan
dc.contributor.authorEraksoy, Ömer Haluk
dc.contributor.authorAksu, Kenan
dc.contributor.authorErtunç, Barış
dc.contributor.authorKorten, Volkan
dc.contributor.authorCeylan, Bahadır
dc.contributor.authorMert, Ali
dc.identifier.citationArslan, F., Alp, Ş., Büyükaşık, Y., Cömert Özkan, M., Şahin, F., Başaran, S. ... Mert, A. (2018). Hemophagocytic lymphohistiocytosis in adults: Low incidence of primary neoplasm as a trigger in a case series from Turkey. Mediterranean Journal of Hematology and Infectious Diseases, 10.
dc.descriptionWOS: 000443683300001en_US
dc.descriptionPubMed ID: 30210740en_US
dc.description.abstractHemophagocytic Lymphohistiocytosis (HLH) is an indicator of an exaggerated immune response and eventually adverse outcomes. This study aimed to investigate the clinical and laboratory features and outcomes of patients with HLH. The medical records of 26 HLH adult patients (>= 16 years of age) were retrospectively analyzed. Gender, age, the duration of fever, time to diagnosis, etiology and laboratory data were extracted from the records. The mean age was 38 +/- 18 years, and 15 (58%) patients were female. A total of nine cases had infectious diseases; four cases had rheumatologic diseases, three cases had hematological malignancies while nine cases could not have a definitive diagnosis. The median time to detection of HLH was 20 days (IQR: 8-30 d). Of the 25 patients, 11 (44%) died. The erythrocyte sedimentation rates of the surviving and non-surviving patients were 39 +/- 22 mm/h and 15 +/- 13 mm/h, respectively. When a long-lasting fever is complicated by bicytopenia or pancytopenia (especially), clinicians should promptly consider the possibility of HLH syndrome to improve patients' prognosis.en_US
dc.publisherPagepress Publicationsen_US
dc.rightsAttribution-NonCommercial 4.0 International*
dc.subjectHemophagocytic Lymphohistiocytosisen_US
dc.subjectFever of Unknown Originen_US
dc.titleHemophagocytic lymphohistiocytosis in adults: Low incidence of primary neoplasm as a trigger in a case series from Turkeyen_US
dc.relation.journalMediterranean Journal of Hematology and Infectious Diseasesen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalıen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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