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dc.contributor.authorKaraarslan, Numan
dc.contributor.authorBatmaz, Ahmet Güray
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorÇalışkan, Tezcan
dc.contributor.authorYaşar Şirin, Duygu
dc.contributor.authorKaplan, Necati
dc.contributor.authorÖznam, Kadir
dc.contributor.authorAteş, Özkan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:17Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:17Z
dc.date.issued2018en_US
dc.identifier.citationKaraarslan, N., Batmaz, A., Yılmaz, İ., Özbek, H., Çalışkan, T., Yaşar Şirin, D. ... Ateş, Ö. (2018). Effect of naproxen on proliferation and differentiation of primary cell cultures isolated from human cartilage tissue. Experimental and Therapeutic Medicine, 16(3), 1647-1654. https://dx.doi.org/10.3892/etm.2018.6351en_US
dc.identifier.issn1792-0981
dc.identifier.issn1792-1015
dc.identifier.urihttps://dx.doi.org/10.3892/etm.2018.6351
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1937
dc.descriptionWOS: 000443738300011en_US
dc.descriptionPubMed ID: 30186383en_US
dc.description.abstractNon-steroidal anti-inflammatory drugs (NSAIDs) that are applied through oral, injectable or topical routes have been widely used in painful and inflammatory musculoskeletal diseases. The current study aimed to determine whether naproxen, an aryl acetic acid derivative with analgesic and anti-inflammatory effects, has a toxic effect on human chondrocytes. Samples containing monolayer primary chondrocyte cultures were prepared following resection from osteochondral tissues obtained from patients with gonarthrosis. Cell viability, toxicity and proliferation and levels of stage-specific embryonic antigen-1, a precursor to human prechondrocytes, were evaluated spectrophotometrically. The results from the untreated control group were compared with those of the study groups, where naproxen was administered in varying doses (1-1,000 mu M). Surface morphologies of the cells were compared using inverted light and environmental scanning electron microscopy. Treatment groups were compared by analysis of variance with Tukey's honest difference post hoc test. P<0.01 was considered to indicate a statistically significant difference. The research revealed significant changes to proliferation and differentiation of chondrocytes in all treatment groups (P<0.01). Naproxen was demonstrated to suppress chondrocyte proliferation and differentiation, which may be an important factor to consider when prescribing this medication to patients.en_US
dc.language.isoengen_US
dc.publisherSpandidos Publications Ltden_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAryl Acetic Aciden_US
dc.subjectChondrotoxicityen_US
dc.subjectProliferationen_US
dc.subjectStage-Specific Embryonic Antigen-1en_US
dc.titleEffect of naproxen on proliferation and differentiation of primary cell cultures isolated from human cartilage tissueen_US
dc.typearticleen_US
dc.relation.ispartofExperimental and Therapeutic Medicineen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Ana Bilim Dalıen_US
dc.authorid0000-0003-2003-6337en_US
dc.authorid0000-0002-8084-7855en_US
dc.identifier.volume16en_US
dc.identifier.issue3en_US
dc.identifier.startpage1647en_US
dc.identifier.endpage1654en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.3892/etm.2018.6351en_US
dc.identifier.wosqualityQ3en_US
dc.identifier.scopusqualityQ2en_US


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