dc.contributor.author | Öncül, Merve | |
dc.contributor.author | Dilsiz, Pelin | |
dc.contributor.author | Ateş Öz, Edanur | |
dc.contributor.author | Ateş, Tayfun | |
dc.contributor.author | Aklan, İltan | |
dc.contributor.author | Çelik, Eşref | |
dc.contributor.author | Sayar Atasoy, Nilüfer | |
dc.contributor.author | Atasoy, Deniz | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:50:13Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:50:13Z | |
dc.date.issued | 2018 | en_US |
dc.identifier.citation | Öncül, M., Dilsiz, P., Ateş Öz, E., Ateş, T., Aklan, I., Çelik, E. ... Atasoy, D. (2018). Impaired melanocortin pathway function in prader-willi syndrome gene-magel2 deficient mice. Human Molecular Genetics, 27(18), 3129-3136. https://dx.doi.org/10.1093/hmg/ddy216 | en_US |
dc.identifier.issn | 0964-6906 | |
dc.identifier.issn | 1460-2083 | |
dc.identifier.uri | https://dx.doi.org/10.1093/hmg/ddy216 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/1915 | |
dc.description | WOS: 000444203500001 | en_US |
dc.description | PubMed ID: 29878108 | en_US |
dc.description.abstract | Prader-Willi Syndrome (PWS) is a neurodevelopmental disorder causing social and learning deficits, impaired satiety and severe childhood obesity. Genetic underpinning of PWS involves deletion of a chromosomal region with several genes, including MAGEL2, which is abundantly expressed in the hypothalamus. Of appetite regulating hypothalamic cell types, both AGRP and POMC-expressing neurons contain Magel2 transcripts but the functional impact of its deletion on these cells has not been fully characterized. Here, we investigated these key neurons in Magel2-nullmice in terms of the activity levels at different energy states as well as their behavioral function. Using cell type specific ex vivo electrophysiological recordings and in vivo chemogenetic activation approaches we evaluated impact of Magel2 deletion on AGRP and POMC-neuron induced changes in appetite. Our results suggest that POMC neuron activity profile as well as its communication with downstream targets is significantly compromised, while AGRP neuron function with respect to short term feeding is relatively unaffected in Magel2 deficiency. | en_US |
dc.description.sponsorship | European Molecular Biology Organisation (EMBO) Installation Grant [2539] | en_US |
dc.description.sponsorship | This work was supported by European Molecular Biology Organisation (EMBO) Installation Grant to D.A., grant no. 2539. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Oxford University Press | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Prader-Willi Syndrome | en_US |
dc.subject | Obesity | en_US |
dc.subject | PWS Patients | en_US |
dc.title | Impaired melanocortin pathway function in prader-willi syndrome gene-magel2 deficient mice | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Human Molecular Genetics | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | en_US |
dc.authorid | 0000-0003-4604-4765 | en_US |
dc.authorid | 0000-0002-3247-613X | en_US |
dc.authorid | 0000-0002-3325-8820 | en_US |
dc.identifier.volume | 27 | en_US |
dc.identifier.issue | 18 | en_US |
dc.identifier.startpage | 3129 | en_US |
dc.identifier.endpage | 3136 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1093/hmg/ddy216 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.scopusquality | Q1 | en_US |