Dry eye assessment in patients with vitamin D deficiency
Erdur, Sevil Karaman
Kocabora, Mehmet Selim
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CitationDemirci, G., Karaman Erdur, S., Özsütçü, M., Eliaçık, M., Ölmüşçelik, O., Aydın, R. ... Kocabora, M. S. (2018). Dry eye assessment in patients with vitamin D deficiency. Eye and Contact Lens, 44(Supplement: 1), S62-S65. https://dx.doi.org/10.1097/ICL.0000000000000325
Objectives: The aim of this study was to evaluate tear film function in patients with vitamin D deficiency. Methods: In a single center, 60 eyes of 30 patients with vitamin D deficiency (group 1), and 60 eyes of 30 healthy individuals (group 2) were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I test, tear break-up time (TBUT), scoring of ocular surface fluorescein staining using a modified Oxford scale, and tear osmolarity. Results: Tear osmolarity values, OSDI, and Oxford scale scores were significantly higher in group 1 (309 +/- 9 mOsm/L, 35.78 +/- 21.44 and 1.3 +/- 0.9, respectively) compared with group 2 (295610 mOsm/L, 18.69 +/- 17.21 and 0.4 +/- 0.8, respectively) (P<0.001 for all). Schirmer I test and TBUT results in group 1 (8.5 +/- 3.7 mm and 8.7 +/- 0.6 sec, respectively) were significantly lower compared with group 2 (16.6 +/- 2.4 and 18.1 +/- 0.5, respectively) (P<0.001 for all). Conclusions: This study demonstrates that vitamin D deficiency is associated with tear hyperosmolarity and tear film dysfunction. Patients with vitamin D deficiency may be prone to dry eye.