dc.contributor.author | Aydın, Mehmet Şerif | |
dc.contributor.author | Yiğit, Esra Nur | |
dc.contributor.author | Vatandaşlar, Emre | |
dc.contributor.author | Erdoğan, Ender | |
dc.contributor.author | Öztürk, Gürkan | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:50:10Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:50:10Z | |
dc.date.issued | 2018 | en_US |
dc.identifier.citation | Aydın, M. Ş., Yiğit, E., Vatandaşlar, E., Erdoğan, E. ve Öztürk, G. (2018). Transfer and integration of breast milk stem cells to the brain of suckling pups. Scientific Reports, 8. https://dx.doi.org/10.1038/s41598-018-32715-5 | en_US |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://dx.doi.org/10.1038/s41598-018-32715-5 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/1903 | |
dc.description | WOS: 000445336600057 | en_US |
dc.description | PubMed ID: 30250150 | en_US |
dc.description.abstract | Beside its unique nutritional content breast milk also contains live cells from the mother. Fate of these cells in the offspring has not been adequately described. In this study, we aimed to detect and identify maternal cells in the suckling's blood and the brain. Green fluorescent protein expressing transgenic female mice (GFP+) were used as foster mothers to breastfeed wildtype newborn pups. One week and two months after the birth, blood samples and brains of the sucklings were analyzed to detect presence of GFP+ cells by fluorescence activated cell sorting, polymerase chain reaction and immunohistochemistry on the brain sections and optically cleared brains. The tests confirmed that maternal cells were detectable in the blood and the brain of the pups and that they differentiated into both neuronal and glial cell types in the brain. This phenomenon represents breastfeeding - induced microchimerism in the brain with functional implications remain to be understood. | en_US |
dc.description.sponsorship | The Scientific and Technological Research Council of Turkey (TUBITAK) [114R078] | en_US |
dc.description.sponsorship | This project was supported by "The Scientific and Technological Research Council of Turkey" (TUBITAK) with a grant number 114R078. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Chimerism | en_US |
dc.subject | Pregnancy | en_US |
dc.subject | Fetal Microchimerism | en_US |
dc.title | Transfer and integration of breast milk stem cells to the brain of suckling pups | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Scientific Reports | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | en_US |
dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-6393-1465 | en_US |
dc.authorid | 0000-0001-9037-5217 | en_US |
dc.authorid | 0000-0003-0352-1947 | en_US |
dc.identifier.volume | 8 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1038/s41598-018-32715-5 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.scopusquality | Q1 | en_US |