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dc.contributor.authorOkur, Mehmet Evren
dc.contributor.authorAyla, Şule
dc.contributor.authorPolat, Derya Çiçek
dc.contributor.authorGünal, Mehmet Yalçın
dc.contributor.authorYoltaş, Ayşegül
dc.contributor.authorBiçeroğlu, Özge
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:10Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:10Z
dc.date.issued2018en_US
dc.identifier.citationOkur, M. E., Ayla, Ş., Polat, D. Ç., Günal, M. Y., Yoltaş, A. ve Biçeroğlu, Ö. (2018). Novel insight into wound healing properties of methanol extract of Capparis ovata Desf. var. palaestina Zohary fruits. Journal of Pharmacy and Pharmacology, 70(10), 1401-1413. https://dx.doi.org/10.1111/jphp.12977en_US
dc.identifier.issn0022-3573
dc.identifier.issn2042-7158
dc.identifier.urihttps://dx.doi.org/10.1111/jphp.12977
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1900
dc.descriptionWOS: 000443809400012en_US
dc.descriptionPubMed ID: 29984824en_US
dc.description.abstractObjectivesThe objective of this study was to investigate the wound healing activity of Capparis ovata var. palaestina fruit extract in mice. For this aim, wound healing, invitro antimicrobial and antioxidant activities, HPLC, phenolic and flavonoid compounds analyses were performed. MethodsThe wound healing effect was tested by excisional wound model. Wound closure was measured for 14days and at 14th day wound healing was assessed by levels of TGF-, VEGF, COL1A1 and angiogenesis, granulation tissue thickness, epidermal and dermal regeneration. The antioxidant activity was calculated by DPPH and ABTS free radical scavenging assays. Antimicrobial ability was evaluated by minimum inhibitory concentration and agar well diffusion tests. Key findingsThe extract indicated significant antioxidant activity while it also exhibited antimicrobial activity. Rutin was found in the extract according to HPLC study. Moreover, the extract was found to have rich phenolic and flavonoid contents. Histological evaluation showed that extract group induced significant (P<0.001) wound healing activity compared to control group. Furthermore, extract group increased wound healing rates by promoting granulation tissue, epidermal regeneration, angiogenesis, collagen, TGF- and VEGF. ConclusionsThe results clarified that the extract possesses antioxidant, antimicrobial activity and thus could provide a valuable contribution to the wound healing.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAntimicrobialen_US
dc.subjectAntioxidanten_US
dc.subjectCapparis Ovata Varen_US
dc.subjectPalaestinaen_US
dc.subjectExtracten_US
dc.subjectWound Healingen_US
dc.titleNovel insight into wound healing properties of methanol extract of Capparis ovata Desf. var. palaestina Zohary fruitsen_US
dc.typearticleen_US
dc.relation.journalJournal of Pharmacy and Pharmacologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.authorid0000-0003-2143-5268en_US
dc.identifier.volume70en_US
dc.identifier.issue10en_US
dc.identifier.startpage1401en_US
dc.identifier.endpage1413en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1111/jphp.12977en_US


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