dc.contributor.author | Surov, Alexey | |
dc.contributor.author | Ginat, Daniel Thomas | |
dc.contributor.author | Lim, Tchoyoson | |
dc.contributor.author | Cabada, Teresa | |
dc.contributor.author | Başkan, Özdil | |
dc.contributor.author | Schob, Stefan | |
dc.contributor.author | Meyer, Hans Jonas | |
dc.contributor.author | Gihr, Georg Alexander | |
dc.contributor.author | Horvath-Rizea, Diana | |
dc.contributor.author | Hamerla, Gordian | |
dc.contributor.author | Hoffmann, Karl Titus | |
dc.contributor.author | Wienke, Andreas | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:50:09Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:50:09Z | |
dc.date.issued | 2018 | en_US |
dc.identifier.citation | Surov, A., Ginat, D., Lim, T., Cabada, T., Başkan, Ö., Schob, S. ... Wienke, A. (2018). Histogram analysis parameters apparent diffusion coefficient for distinguishing high and low-grade meningiomas: A multicenter study. Translational Oncology, 11(5), 1074-1079. https://dx.doi.org/10.1016/j.tranon.2018.06.010 | en_US |
dc.identifier.issn | 1936-5233 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.tranon.2018.06.010 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/1898 | |
dc.description | WOS: 000444013200002 | en_US |
dc.description | PubMed ID: 30005209 | en_US |
dc.description.abstract | Low grade meningiomas have better prognosis than high grade meningiomas. The aim of this study was to measure apparent diffusion coefficient (ADC) histogram analysis parameters in different meningiomas in a large multicenter sample and to analyze the possibility of several parameters for predicting tumor grade and proliferation potential. Overall, 148 meningiomas from 7 institutions were evaluated in this retrospective study. Grade 1 lesions were diagnosed in 101 (68.2%) cases, grade 2 in 41 (27.7%) patients, and grade 3 in 6 (4.1%) patients. All tumors were investigated by MRI (1.5T scanner) by using diffusion weighted imaging (b values of 0 and 1000 s/mm (2)). For every lesion, the following parameters were calculated: mean ADC, maximum ADC, minimum ADC, median ADC, mode ADC, ADC percentiles P10, P25, P75, P90, kurtosis, skewness, and entropy. The comparison of ADC values was performed by Mann Whitney-U test. Correlation between different ADC parameters and KI 67 was calculated by Spearman's rank correlation coefficient. Grade 2/3 meningiomas showed statistically significant lower ADC histogram analysis parameters in comparison to grade 1 tumors, especially ADC median. A threshold value of 0.82 for ADC median to predict tumor grade was estimated (sensitivity = 82.2%, specificity = 63.8%, accuracy = 76.4%, positive and negative predictive values were 83% and 62.5%, respectively). All ADC parameters except maximum ADC showed weak significant correlations with KI 67, especially ADC P25 (P =-.340, P = .0001). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Science Inc | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Meningioma | en_US |
dc.subject | Neoplasms | en_US |
dc.subject | Atypical Meningiomas | en_US |
dc.title | Histogram analysis parameters apparent diffusion coefficient for distinguishing high and low-grade meningiomas: A multicenter study | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Translational Oncology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı | en_US |
dc.identifier.volume | 11 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 1074 | en_US |
dc.identifier.endpage | 1079 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.tranon.2018.06.010 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q2 | en_US |