dc.contributor.author | Babiloni, Claudio | |
dc.contributor.author | del Percio, Claudio | |
dc.contributor.author | Lizio, Roberta | |
dc.contributor.author | Noce, Giuseppe | |
dc.contributor.author | Lopez, Susanna | |
dc.contributor.author | Soricelli, Andrea | |
dc.contributor.author | Ferri, Raffaele | |
dc.contributor.author | Pascarelli, Maria Teresa | |
dc.contributor.author | Catania, Valentine | |
dc.contributor.author | Nobili, Flavio | |
dc.contributor.author | Arnaldi, Dario | |
dc.contributor.author | Fama, Francesco | |
dc.contributor.author | Orzi, Francesco | |
dc.contributor.author | Buttinelli, Carla | |
dc.contributor.author | Giubilei, Franco | |
dc.contributor.author | Bonanni, Laura | |
dc.contributor.author | Franciotti, Raffaella | |
dc.contributor.author | Onofrj, Marco | |
dc.contributor.author | Stirpe, Paola | |
dc.contributor.author | Fuhr, Peter | |
dc.contributor.author | Gschwandtner, Ute | |
dc.contributor.author | Ransmayr, Gerhard | |
dc.contributor.author | Fraioli, Lucia | |
dc.contributor.author | Parnetti, Lucilla | |
dc.contributor.author | Farotti, Lucia | |
dc.contributor.author | Pievani, Michela | |
dc.contributor.author | D'Antonio, Fabrizia | |
dc.contributor.author | de Lena, Carlo | |
dc.contributor.author | Güntekin, Bahar | |
dc.contributor.author | Hanoğlu, Lütfü | |
dc.contributor.author | Yener, Görsev | |
dc.contributor.author | Emek Savaş, Derya Durusu | |
dc.contributor.author | Triggiani, Antonio Ivano | |
dc.contributor.author | Taylor, John Paul | |
dc.contributor.author | McKeith, Ian | |
dc.contributor.author | Stocchi, Fabrizio | |
dc.contributor.author | Vacca, Laura | |
dc.contributor.author | Frisoni, Giovanni B. | |
dc.contributor.author | de Pandis, Maria Francesca | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:49:55Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:49:55Z | |
dc.date.issued | 2019 | en_US |
dc.identifier.citation | Babiloni, C., del Percio, C., Lizio, R., Noce, G., Lopez, S., Soricelli, A. … de Pandis, M. F. (2019). Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms. Neurobiology of Aging, 73, 9-20. https://dx.doi.org/10.1016/j.neurobiolaging.2018.08.010 | en_US |
dc.identifier.issn | 0197-4580 | |
dc.identifier.issn | 1558-1497 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.neurobiolaging.2018.08.010 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/1819 | |
dc.description | WOS: 000450412900002 | en_US |
dc.description | PubMed ID: 30312790 | en_US |
dc.description.abstract | We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8-12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (<4 Hz) sources. Widespread frontal and temporal alpha sources exhibited an increase in PD with dementia compared with PD with mild cognitive impairment and PD with normal cognition groups, as function of dopamine depletion severity, typically greater in the former than the latter groups. A daily dose of levodopa induced a widespread reduction in cortical delta and alpha sources in a subgroup of 13 PD patients under standard chronic dopaminergic regimen. In PD patients in quiet wakefulness, alpha cortical source activations may reflect an excitatory effect of dopamine neuromodulation. | en_US |
dc.description.sponsorship | H2020 Marie S. Curie ITN-ETN project | en_US |
dc.description.sponsorship | The present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Body. The members and institutional affiliations of the Consortia are reported in the cover page of this article. The research activities of the Unit of University of Rome "La Sapienza" were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title " BBDiag" (http://bbdiag-itnetn.eu).The authors thank Mrs. Jessica Janson and Mrs. Marina Selivanova for their support to those activities in the framework of the BBDiag project. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Science Inc | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Functional Brain Connectivity | en_US |
dc.subject | Resting State EEG Rhythms | en_US |
dc.subject | Mild Cognitive Impairment Due To Alzheimer's Disease (ADMCI) | en_US |
dc.subject | Mild Cognitive Impairment Due To Parkinson's Disease (PDMCI) | en_US |
dc.title | Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Neurobiology of Aging | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-0860-0524 | en_US |
dc.authorid | 0000-0003-4292-5717 | en_US |
dc.authorid | 0000-0002-0860-0524 | en_US |
dc.authorid | 0000-0003-4292-5717 | en_US |
dc.identifier.volume | 73 | en_US |
dc.identifier.startpage | 9 | en_US |
dc.identifier.endpage | 20 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.neurobiolaging.2018.08.010 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q1 | en_US |