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dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorYıldız, Sultan
dc.contributor.authorÇakır, Tansel
dc.contributor.authorHanoğlu, Taha
dc.contributor.authorYuluğ, Burak
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:51Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:51Z
dc.date.issued2019en_US
dc.identifier.citationHanoğlu, L., Yıldız, S., Çakır, T., Hanoğlu, T. ve Yuluğ, B. (2019). FDG-PET scanning shows distributed changes in cortical activity associated with visual hallucinations in eye disease. Endocrine Metabolic & Immune Disordersdrug Targets, 19(1), 84-89. https://dx.doi.org/10.2174/1871530318666180830112709en_US
dc.identifier.issn1871-5303
dc.identifier.issn2212-3873
dc.identifier.urihttps://dx.doi.org/10.2174/1871530318666180830112709
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1793
dc.descriptionWOS: 000458024300011en_US
dc.descriptionPubMed ID: 30160221en_US
dc.description.abstractBackground and Objective: Charles Bonnet Syndrome (CBS) has been defined as complex visual hallucinations (CVH) due to visual loss. The underlying mechanism of CBS is not clear and the underlying pathophysiology of the visual hallucinations in CBS patients and pure visually impaired patients is still not clear. Methods: In our study, we have scanned three patients with eye disease and CBS (VH+) and three patients with eye disease without CBS (VH-) using FDG-PET. Results: Our results showed underactivity in the pons and overactivity in primary right left visual cortex and inferior parietal cortex in VH- patients and underactivity in left Broca, left inf frontal primary visual cortex and anterior and posterior cingulate cortex in VH+ patients relative to the normative 18F-FDG PET data that was taken from the database consisting of 50 age-matched healthy adults without neuropsychiatric disorders. Conclusion: From this distributed pattern of activity changes, we conclude that the generation of visual hallucination in CBS is associated with bottom-up and top-down mechanism rather than the generally accepted visual deafferentation-related hyperexcitability theory.en_US
dc.language.isoengen_US
dc.publisherBentham Science Publ Ltden_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVisual Hallucinationen_US
dc.subjectCharles Bonnet Syndromeen_US
dc.subject18F-FDG PET Scanningen_US
dc.subjectVisual Deafferentation Theoryen_US
dc.subjectGlaucomaen_US
dc.subjectAge-Related Macular Degenerationen_US
dc.subjectDiabetic Retinopathyen_US
dc.titleFDG-PET scanning shows distributed changes in cortical activity associated with visual hallucinations in eye diseaseen_US
dc.typearticleen_US
dc.relation.ispartofEndocrine Metabolic & Immune Disordersdrug Targetsen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nükleer Tıp Ana Bilim Dalıen_US
dc.authorid0000-0003-4292-5717en_US
dc.authorid0000-0003-1980-700Xen_US
dc.authorid0000-0002-7685-2766en_US
dc.authorid0000-0002-9704-6173en_US
dc.identifier.volume19en_US
dc.identifier.issue1en_US
dc.identifier.startpage84en_US
dc.identifier.endpage89en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.2174/1871530318666180830112709en_US
dc.identifier.wosqualityQ3en_US
dc.identifier.scopusqualityQ3en_US


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