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dc.contributor.authorAcar Şah, Esra
dc.contributor.authorCelep, Engin
dc.contributor.authorYeşilada, Erdem
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:50Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:50Z
dc.date.issued2019en_US
dc.identifier.citationAcar Şah, E., Celep, E. ve Yeşilada, E. (2019). In vitro bioavailability studies on phytochemical profile and antioxidant activity potential of clematis viticella L. Journal of Research in Pharmacy, 23(2), 326-335. https://dx.doi.org/10.12991/jrp.2019.140en_US
dc.identifier.issn2630-6344
dc.identifier.urihttps://dx.doi.org/10.12991/jrp.2019.140
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1784
dc.descriptionWOS: 000459615300021en_US
dc.description.abstractSince biotransformation processes generally affect the biological activities of phytochemical compounds, bioavailability is one of the primary steps in determining the potency of the activity. Previous studies have shown that in vitro antioxidant capacity of phytochemicals cannot completely reflect real health benefits. Clematis species (Ranunculaceae) are used to eliminate the symptoms of many diseases including particularly in the treatment of rheumatic diseases in Turkey, however the number of studies conducted is limited. In the light of this information, the total phytochemical profile of the extract of aerial parts of C. viticella prepared with 80% methanol and the gastrointestinal digestion products and the antioxidant activity profile were evaluated by subjecting them to the in vitro simulation model of the human digestive tract in the study. It was observed that both total phytochemical content and antioxidant activity decreased after simulated human digestion. Moreover, this study was shown potential bioaccessibility and bioavailability of total phenol, phenolic acid, flavonoid, and saponin content found in the aerial parts of Clematis viticella were reduced. Consequently, these indicate that it can result from the complicated interaction of compounds in the plant matrix in an in vitro simulated human digestion.en_US
dc.language.isoengen_US
dc.publisherMarmara Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectClematis Viticella L.en_US
dc.subjectRanunculaceaeen_US
dc.subjectPhenolic Profileen_US
dc.subjectAntioxidant Activityen_US
dc.subjectIn Vitro Digestion Simulation Modelen_US
dc.subjectBioavailabilityen_US
dc.subjectBioaccessibilityen_US
dc.titleIn vitro bioavailability studies on phytochemical profile and antioxidant activity potential of clematis viticella L.en_US
dc.typearticleen_US
dc.relation.journalJournal of Research in Pharmacyen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalıen_US
dc.authorid0000-0003-38824526en_US
dc.identifier.volume23en_US
dc.identifier.issue2en_US
dc.identifier.startpage326en_US
dc.identifier.endpage335en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.12991/jrp.2019.140en_US


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