Graft-versus-host disease in a child with neuroblastoma after autologous stem cell transplantation
Genç, Dildar Bahar
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KünyeYaman, Y., Baysoy, G., Keleşoğlu, E., Özdilli, K., Erdoğan Çakır, A., Genç, D. B. ... Anak, S. (2019). Graft-versus-host disease in a child with neuroblastoma after autologous stem cell transplantation. Wspolczesna Onkologia-Contemporary Oncology, 23(1), 59-62. https://dx.doi.org/10.5114/wo.2019.83815
In the pediatric population, hematopoietic stem cell transplantation (HSCT) is used to treat a wide variety of diseases, both malignant and nonmalignant. For many of these diseases, HSCT is a well-established treatment. Acute graft-versus-host disease (GVHD) continues to be a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Graft versus host disease is a common complication of allo-SCT which is induced by donor T cell recognition of recipient alloantigens. The occurrence of autologous GVHD suggests that inappropriate recognition of host self-antigens may occur. GVHD in patients who received autologous HSCT is extremely rare compared to patients who received allogeneic HSCT. We present the case of a 4-year-old girl with metastatic neuroblastoma who spontaneously developed autologous GVHD after autologous HSCT.