dc.contributor.author | Sakul, Arzu | |
dc.contributor.author | Ozansoy, Mehmet | |
dc.contributor.author | Elibol, Birsen | |
dc.contributor.author | Ayla, Şule | |
dc.contributor.author | Günal, Mehmet Yalçın | |
dc.contributor.author | Yozgat, Yasemin | |
dc.contributor.author | Basağa, Hüveyda | |
dc.contributor.author | Şahin, Kazım | |
dc.contributor.author | Kazancıoğlu, Rümeyza | |
dc.contributor.author | Kılıç, Ulkan | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:49:46Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:49:46Z | |
dc.date.issued | 2019 | en_US |
dc.identifier.citation | Sakul, A, Ozansoy, M., Elibol, B., Ayla, Ş., Günal, M. Y., Yozgat, Y. … Kılıç, U. (2019). Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice. Turkish Journal of Biology, 43(3), 179-188. https://dx.doi.org/10.3906/biy-1902-77 | en_US |
dc.identifier.issn | 1300-0152 | |
dc.identifier.issn | 1303-6092 | |
dc.identifier.uri | https://dx.doi.org/10.3906/biy-1902-77 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/1753 | |
dc.description | WOS: 000471268100003 | en_US |
dc.description.abstract | The clinical use of cisplatin, which is a first-line anticancer agent, is highly restricted due to its adverse effects on kidneys that lead to nephrotoxicity. Therefore, some potential reno-protective substances have been used in combination with cisplatin to cope with nephrotoxicity. Due to its high antitumor activity and oxygen-carrying capacity, we investigated the molecular effects of squalene against cisplatin-induced oxidative stress and kidney damage in mice. Single dose of cisplatin (7 mg/kg) was given to male Balb/c mice. Squalene (100 mg/kg/day) was administered orogastrically to mice for 10 days. Following sacrification, molecular alterations were investigated as analysis of the levels of oxidative stress index (OSI), inflammatory cytokines and cell survival-related proteins in addition to histopathological examinations in mice kidney tissue. The level OSI and Interferon-gamma (IFN-gamma) decreased in the cisplatin and squalene cotreated mice compared to cisplatin-treated mice. Squalene treatment also increased the activation of protein kinase B (AKT). Furthermore, cisplatin-induced inactivation of mammalian target of rapamycin (mTOR) and histopathological damages were reversed by squalene. It may be suggested that squalene ameliorated the cisplatin-induced histopathological damages in the kidney through activation of AKT/mTOR signaling pathway by regulating the balance of the redox system due to its antioxidative effect. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Tubitak Scientific & Technical Research Council Turkey | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | AKT | en_US |
dc.subject | Cisplatin-Induced Nephrotoxicity | en_US |
dc.subject | Mice | en_US |
dc.subject | mTOR | en_US |
dc.subject | Oxidative-Stress | en_US |
dc.subject | Squalene | en_US |
dc.title | Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Turkish Journal of Biology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | en_US |
dc.authorid | 0000-0002-9354-0000 | en_US |
dc.authorid | 0000-0002-1079-8832 | en_US |
dc.authorid | 0000-0003-2143-5268 | en_US |
dc.authorid | 0000-0003-1580-8371 | en_US |
dc.identifier.volume | 43 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 179 | en_US |
dc.identifier.endpage | 188 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.3906/biy-1902-77 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.scopusquality | Q3 | en_US |