Maternal serum sestrin 2 levels in preeclampsia and their relationship with the severity of the disease

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2019Author
Tayyar, Ahter TanayTayyar, Ahmet
Kozalı, Şükran
Karakuş, Resul
Eser, Ahmet
Yayla, Çiğdem Abide
Yalçın, Emel Tuğçe
Dağ, İsmail Dağ
Eroğlu, Mustafa
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Tayyar, A., Tayyar, A. T., Kozalı, Ş., Karakuş, R., Eser, A., Yayla, Ç. A. … Eroğlu, M. (2019). Maternal serum sestrin 2 levels in preeclampsia and their relationship with the severity of the disease. Hypertension In Pregnancy, 38(1), 13-19. https://dx.doi.org/10.1080/10641955.2018.1540702Abstract
Objective: To investigate sestrin 2 (SESN2) levels in preeclampsia (PE) cases and uncomplicated pregnancies. Methods: Cross-sectional study including 26 pregnant women with PE, 24 with severe-PE, and 30 randomly selected healthy pregnant women. Results: The mean arterial pressure, severe proteinuria, number of HELLP syndrome cases, and serum SESN2 levels in the severe PE group were significantly higher than those in the other groups (p <0.001, p <0.001, p = 0.006, and p = 0.004, respectively). Negative correlation was found between the birth interval (r =-.262, p = 0.019) and the SESN2 level. Conclusion: SESN2 seems to play a role in the pathophysiology of PE, especially in severe PE cases.
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Hypertension In PregnancyVolume
38Issue
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