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dc.contributor.authorKaraaslan, Pelin
dc.contributor.authorSevmiş, Şinasi
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:43Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:43Z
dc.date.issued2019en_US
dc.identifier.citationKaraaslan, P. ve Sevmiş, Ş. (2019). Effect of terlipressin infusion therapy on recipient's hepatic and renal functions in living donor liver transplantations: Experience from a tertiary hospital. Nigerian Journal of Clinical Practice, 22(2), 265-269. https://dx.doi.org/10.4103/njcp.njcp_268_17en_US
dc.identifier.issn1119-3077
dc.identifier.urihttps://dx.doi.org/10.4103/njcp.njcp_268_17
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1735
dc.descriptionWOS: 000458370600019en_US
dc.descriptionPubMed ID: 30729953en_US
dc.description.abstractBackground: Patients with end-stage liver disease are prone to hemodynamic disturbances which may be aggravated with liver transplantation. Blood pooling in splanchnic area and portal hypertension cause reduction in central blood volume. Terlipressin reduces mesenteric and hepatic blood flow, causing vasoconstriction in the smooth muscles of the arteries in the splanchnic region. Objective: We investigated the efficacy of perioperative terlipressin infusion in patients who received living donor liver transplantation (LDLT) on hepatic and renal functions. Design: Retrospective. Setting: University hospital. Method: The study included 86 adult patients who received LDLT, due to end-stage hepatic disease, between April 2014 and July 2016 in our institute. Data were collected by searching the medical archives of patients. A standard anesthesia protocol was administered to all patients. In a selected group of patients, terlipressin infusion was initiated at 3 mg/kg/h, immediately after anesthesia was induced. The dose was halved following arterial anastomosis and was continued at this dose for the subsequent 3 days. Patients who received terlipressin infusion were compared with patients who did not receive it. Main Outcome Measures: There is no evidence in this trial to show evidence of effectiveness as a result of terlipressin infusion. Results: Patients in the terlipressin group were statistically significantly older. Central venous pressure, cardiac index, global end diastolic volume, and extravascular lung volume did not show significant differences between the groups. Urine output was similar in both groups; however, regarding the use of packed red blood cells and fresh frozen plasma, terlipressin group patients needed more packs. Perioperative liver function tests were similar between the groups except for aspartate aminotransferase and alanine aminotransferase values on the first and third postoperative days. Conclusion: Terlipressin infusion was not found to be significantly effective among the liver and kidney function tests. Limitations: This may be a result of randomization defect of our retrospective study design. Many prospective randomized studies should be planned to reach more accurate results.en_US
dc.language.isoengen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectHepatic Function Testsen_US
dc.subjectLiving Related Donor Liver Transplantationen_US
dc.subjectTerlipressinen_US
dc.titleEffect of terlipressin infusion therapy on recipient's hepatic and renal functions in living donor liver transplantations: Experience from a tertiary hospitalen_US
dc.typearticleen_US
dc.relation.journalNigerian Journal of Clinical Practiceen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.authorid0000-0002-5273-1871en_US
dc.identifier.volume22en_US
dc.identifier.issue2en_US
dc.identifier.startpage265en_US
dc.identifier.endpage269en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.4103/njcp.njcp_268_17en_US


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