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dc.contributor.authorZorlu, Nabi
dc.contributor.authorÇapraz, Necip
dc.contributor.authorÖztekin, Esra
dc.contributor.authorBağcı, Başak
dc.contributor.authorDi Biase, Maria A.
dc.contributor.authorZalesky, Andrew
dc.contributor.authorGelal, Fazıl
dc.contributor.authorBora, Emre
dc.contributor.authorDurmaz, Ercan
dc.contributor.authorBeşiroğlu, Lütfullah
dc.contributor.authorSarıciçek, Aybala
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:41Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:41Z
dc.date.issued2019en_US
dc.identifier.citationÇapraz, N., Zorlu, N., Öztekin, E., Bağcı, B., Di Biase, M. A., Zalesky, A. ... Sarıçiçek, A. (2019). Rich club and reward network connectivity as endophenotypes for alcohol dependence: A diffusion tensor imaging study. Addiction Biology, 24(2), 265-274. https://dx.doi.org/10.1111/adb.12599en_US
dc.identifier.issn1355-6215
dc.identifier.issn1369-1600
dc.identifier.urihttps://dx.doi.org/10.1111/adb.12599
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1719
dc.descriptionWOS: 000458437000010en_US
dc.descriptionPubMed ID: 29280246en_US
dc.description.abstractWe aimed to examine the whole-brain white matter connectivity and local topology of reward system nodes in patients with alcohol use disorder (AUD) and unaffected siblings, relative to healthy comparison individuals. Diffusion-weighted magnetic resonance imaging scans were acquired from 18 patients with AUD, 15 unaffected siblings of AUD patients and 15 healthy controls. Structural networks were examined using network-based statistic and connectomic analysis. Connectomic analysis showed a significant ordered difference in normalized rich club organization (AUD <Siblings <Controls). We also found rank ordered differences (Control> Sibling> AUD) for both nodal clustering coefficient and nodal local efficiency in reward system nodes, particularly left caudate, right putamen and left hippocampus. Network-based statistic analyses showed that AUD group had significantly weaker connectivity than controls in the right hemisphere, mostly in the edges connecting putamen and hippocampus with other brain regions. Our results suggest that reward system network abnormalities, especially in subcortical structures, and impairments in rich-club organization might be related to the familial predisposition for AUD.en_US
dc.description.sponsorshipNHMRC Career Development Fellowship [1047648]; Rotary Health Ian Scott PhD Scholarship in Mental Healthen_US
dc.description.sponsorshipA. Z. was supported by NHMRC Career Development Fellowship (grant 1047648). M. D. B. was supported by the Rotary Health Ian Scott PhD Scholarship in Mental Health.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAlcohol Use Disorderen_US
dc.subjectEndophenotypeen_US
dc.subjectRich Cluben_US
dc.subjectStructural Connectivityen_US
dc.subjectWhite Matteren_US
dc.titleRich club and reward network connectivity as endophenotypes for alcohol dependence: A diffusion tensor imaging studyen_US
dc.typearticleen_US
dc.relation.ispartofAddiction Biologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.identifier.volume24en_US
dc.identifier.issue2en_US
dc.identifier.startpage265en_US
dc.identifier.endpage274en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1111/adb.12599en_US
dc.identifier.wosqualityQ1en_US
dc.identifier.scopusqualityQ1en_US


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