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dc.contributor.authorGünal, Mehmet Yalçın
dc.contributor.authorOzansoy, Mehmet
dc.contributor.authorKılıç, Ülkan
dc.contributor.authorKeskin, İlknur
dc.contributor.authorÖzdemir, Ekrem Musa
dc.contributor.authorAslan, İsmail
dc.contributor.authorEren, Zehra
dc.contributor.authorErsavaş, Cenk
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:41Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:41Z
dc.date.issued2019en_US
dc.identifier.citationGünal, M. Y., Ozansoy, M., Kılıç, Ü., Keskin, İ., Özdemir, E. M., Aslan, İ. … Kılıç, E. (2019). Role of erythropoietin and its receptor in the development of endometriosis in rats. Journal of the Turkhish-German Gynecological Association, 20(1), 41-46. https://dx.doi.org/10.4274/jtgga.galenos.2018.2018.0039en_US
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.urihttps://dx.doi.org/10.4274/jtgga.galenos.2018.2018.0039
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1717
dc.descriptionWOS: 000459590500009en_US
dc.descriptionPubMed ID: 29916217en_US
dc.description.abstractObjective: Besides its hematopoietic function, erythropoietin (EPO) may protect tissues from degenerative disorders. As such, EPO and its receptors were revealed in nonhematopoietic cells, including stromal and endometrial epithelial cells. However, the role of EPO in endometrial disorders is still unknown. Here, we aimed to examine the role of EPO and its receptor activation in the development of endometriosis in rats. Material and Methods: Animals were treated with EPO, darbepoietin (the synthetic form of EPO) or EPO's receptor activator, methoxy polyethylene glycol-epoetin beta (MIRCERA), after development of endometriosis. Endometriosis was induced by estrogen-administration following surgical attachment of endometrial surface on the inner abdominal wall. Treatments were started 3 weeks after induction of endometriosis and continued for the following 3 weeks. For the analysis of recurrence of endometriosis, additional analyses were conducted 3 weeks after cessation of treatments. Results: As compared with vehicle-treated animals, lesion size was reduced significantly and recurrence of endometriosis was not observed in all treatment groups. Histopathologic examination revealed that EPO and darbepoietin were more effective than MIRCERA- and vehicle-treated animals. Conclusion: Here we provide evidence that EPO is a promising candidate for the treatment of endometriosis. Our histopathologic results in particular indicate that EPO is more effective than its receptor activator MIRCERA in the development endometriosis.en_US
dc.description.sponsorshipTurkish Academy of Sciences (TUBA)en_US
dc.description.sponsorshipThis work was funded by Turkish Academy of Sciences (TUBA). We would like to thank to Laboratory Technician Nurhayat Donek from Bezmialem University for help throughout this research.en_US
dc.language.isoengen_US
dc.publisherGalenos Yayıncılıken_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndometriosisen_US
dc.subjectDarbepoietinen_US
dc.subjectErythropoietinen_US
dc.subjectMIRCERAen_US
dc.subjectReceptor Activatoren_US
dc.titleRole of erythropoietin and its receptor in the development of endometriosis in ratsen_US
dc.typearticleen_US
dc.relation.journalJournal of the Turkhish-German Gynecological Associationen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Tıbbi Araştırma Merkezi (MEDİTAM)en_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.authorid0000-0001-7702-2441en_US
dc.authorid0000-0002-1079-8832en_US
dc.authorid0000-0002-6895-8560en_US
dc.authorid0000-0002-7059-1884en_US
dc.authorid0000-0001-9416-7757en_US
dc.authorid0000-0001-5134-1014en_US
dc.authorid0000-0001-6494-8923en_US
dc.identifier.volume20en_US
dc.identifier.issue1en_US
dc.identifier.startpage41en_US
dc.identifier.endpage46en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.4274/jtgga.galenos.2018.2018.0039en_US


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