dc.contributor.author | Ataizi, Serdar | |
dc.contributor.author | Özkoç, Mete | |
dc.contributor.author | Kanbak, Güngör | |
dc.contributor.author | Karimkhani, Hadi | |
dc.contributor.author | Burukoğlu Dönmez, Dilek | |
dc.contributor.author | Üstünışık, Növber | |
dc.contributor.author | Öztürk, Buket | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:49:39Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:49:39Z | |
dc.date.issued | 2019 | en_US |
dc.identifier.citation | Ataizi, S., Özkoç, M., Kanbak, G., Karimkhani, H., Dönmez, Dilek B., Üstünışık, N. ... Öztürk, B. (2019). A possible protective role of betain and omega-3 supplementation in traumatic brain injury. Annali Italiani Di Chirurgia, 90(2), 174-181. | en_US |
dc.identifier.issn | 0003-469X | |
dc.identifier.issn | 2239-253X | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/1698 | |
dc.description | WOS: 000471139700013 | en_US |
dc.description | PubMed ID: 31182701 | en_US |
dc.description.abstract | INTRODUCTION: Due to irreversible damage following head trauma, many overlapping pathophysiological events occur including excitotoxicity, acidotoxicity, ionic imbalance, edema, oxidative stress inflammation and apoptosis. MATERIAL AND METHODS: In this this study, after the rats were separated in to groups theserats were fed throughout fourteen days with betaine, omega-3 or betaine+omega-3 combination in physiological limits prior to the trauma. After a closed head trauma, the damaged brain tissues were collected for biochemically and histologically analyses. This examination involved analyses of levels of caspase-3 and cytochrome C and neuron-specific enolase (NSE) levels in brain tissue. RESULTS: These analyses showed that traumatic brain injury (TBI) caused an increase in the levels of caspase-3, cytochrome C and neuron-specific enolase (NED) in the brain tissues examined. DISCUSSION: In this study, apoptotic and/or necrotic cell death via mitochondrial cytochrome C caspase pathway in traumatized cells and neuron-specific enolase (NED) increase indicative of neuronal damage confirmed the research hypothesis. CONCLUSION: Level of the biomarkers induced by brain injury in the groups fed with betaine, omega-3 and betaine+omega-3 combination before the traumatic damage approximated to that of control group values, suggesting that these products may have a neuroprotective role. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Edizioni Luigi Pozzi | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Betain | en_US |
dc.subject | Caspase-3 | en_US |
dc.subject | Cytochrome C and Neuron-Specific Enolase | en_US |
dc.subject | Omega-3 | en_US |
dc.subject | Traumatic Brain Injury | en_US |
dc.title | A possible protective role of betain and omega-3 supplementation in traumatic brain injury | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Annali Italiani Di Chirurgia | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı | en_US |
dc.identifier.volume | 90 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 174 | en_US |
dc.identifier.endpage | 181 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.scopusquality | Q3 | en_US |