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dc.contributor.authorAtaizi, Serdar
dc.contributor.authorÖzkoç, Mete
dc.contributor.authorKanbak, Güngör
dc.contributor.authorKarimkhani, Hadi
dc.contributor.authorBurukoğlu Dönmez, Dilek
dc.contributor.authorÜstünışık, Növber
dc.contributor.authorÖztürk, Buket
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:39Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:39Z
dc.date.issued2019en_US
dc.identifier.citationAtaizi, S., Özkoç, M., Kanbak, G., Karimkhani, H., Dönmez, Dilek B., Üstünışık, N. ... Öztürk, B. (2019). A possible protective role of betain and omega-3 supplementation in traumatic brain injury. Annali Italiani Di Chirurgia, 90(2), 174-181.en_US
dc.identifier.issn0003-469X
dc.identifier.issn2239-253X
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1698
dc.descriptionWOS: 000471139700013en_US
dc.descriptionPubMed ID: 31182701en_US
dc.description.abstractINTRODUCTION: Due to irreversible damage following head trauma, many overlapping pathophysiological events occur including excitotoxicity, acidotoxicity, ionic imbalance, edema, oxidative stress inflammation and apoptosis. MATERIAL AND METHODS: In this this study, after the rats were separated in to groups theserats were fed throughout fourteen days with betaine, omega-3 or betaine+omega-3 combination in physiological limits prior to the trauma. After a closed head trauma, the damaged brain tissues were collected for biochemically and histologically analyses. This examination involved analyses of levels of caspase-3 and cytochrome C and neuron-specific enolase (NSE) levels in brain tissue. RESULTS: These analyses showed that traumatic brain injury (TBI) caused an increase in the levels of caspase-3, cytochrome C and neuron-specific enolase (NED) in the brain tissues examined. DISCUSSION: In this study, apoptotic and/or necrotic cell death via mitochondrial cytochrome C caspase pathway in traumatized cells and neuron-specific enolase (NED) increase indicative of neuronal damage confirmed the research hypothesis. CONCLUSION: Level of the biomarkers induced by brain injury in the groups fed with betaine, omega-3 and betaine+omega-3 combination before the traumatic damage approximated to that of control group values, suggesting that these products may have a neuroprotective role.en_US
dc.language.isoengen_US
dc.publisherEdizioni Luigi Pozzien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBetainen_US
dc.subjectCaspase-3en_US
dc.subjectCytochrome C and Neuron-Specific Enolaseen_US
dc.subjectOmega-3en_US
dc.subjectTraumatic Brain Injuryen_US
dc.titleA possible protective role of betain and omega-3 supplementation in traumatic brain injuryen_US
dc.typearticleen_US
dc.relation.ispartofAnnali Italiani Di Chirurgiaen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.identifier.volume90en_US
dc.identifier.issue2en_US
dc.identifier.startpage174en_US
dc.identifier.endpage181en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.wosqualityQ4en_US
dc.identifier.scopusqualityQ3en_US


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