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dc.contributor.authorÜnal, İsmail
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorAteş, Perihan Seda
dc.contributor.authorEğilmezer, Gizem
dc.contributor.authorAlturfan, Ahmet Ata
dc.contributor.authorYiğitbaşı, Türkan
dc.contributor.authorEmekli Alturfan, Ebru
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:36Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:36Z
dc.date.issued2019en_US
dc.identifier.citationÜnal, İ., Üstündağ, Ünsal V., Ateş, Perihan S., Eğilmezer, G., Alturfan Ahmet A., Yiğitbaşı, T. ... Emekli Alturfan, E. (2019). Rotenone impairs oxidant/antioxidant balance both in brain and intestines in zebrafish. International Journal of Neuroscience, 129(4), 363-368. https://dx.doi.org/10.1080/00207454.2018.1538141en_US
dc.identifier.issn0020-7454
dc.identifier.issn1563-5279
dc.identifier.urihttps://dx.doi.org/10.1080/00207454.2018.1538141
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1673
dc.descriptionWOS: 000461190500007en_US
dc.descriptionPubMed ID: 30334640en_US
dc.description.abstractAim of the study: Rotenone is a commonly used pesticide that inhibits complex I of the mitochondrial electron transport system. Rotenone exposed rats demonstrate many characteristics of Parkinson Disease (PD). Oxidative stress is one of the hallmarks of PD, being the major sources of ROS in the DA neurons. In recent years the strong connection between the intestinal environment and the function of the central nervous system (CNS) has gained widespread popularity. In order to explain the mechanism underlying the GI dysfunction in PD, we aimed to investigate oxidant-antioxidant status in the brain and intestine, as well as locomotor activity, in rotenone exposed zebrafish. Materials and methods: Adult zebrafish were exposed to 2 mg/L rotenone for 30 days. At the end of the experiment, locomotor activity was determined by simple observation. Lipid peroxidation (LPO), nitric oxide (NO) levels, superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST) activities were determined in the homogenates. Results: Locomotor activity decreased in the rotenone exposed zebrafish. LPO increased in both brain and intestines whereas NO increased only in the brain. Decreased GST and CAT activities were found in both tissues whereas SOD activity decreased only in the intestines. Conclusion: As a conclusion, the results of our study support the connection between gut and brain axis in rotenone exposed zebrafish by means of oxidative stress and NO for the first time in literature.en_US
dc.description.sponsorshipMarmara University Scientific Research Projects Commission [SAG-C-YLP-120917-0506]en_US
dc.description.sponsorshipThis study was supported by Marmara University Scientific Research Projects Commission, Project No: SAG-C-YLP-120917-0506.en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis Ltden_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectRotenoneen_US
dc.subjectBrainen_US
dc.subjectIntestineen_US
dc.subjectOxidanten_US
dc.subjectAntioxidanten_US
dc.subjectNitric Oxideen_US
dc.titleRotenone impairs oxidant/antioxidant balance both in brain and intestines in zebrafishen_US
dc.typearticleen_US
dc.relation.journalInternational Journal of Neuroscienceen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.authorid0000-0003-0804-1475en_US
dc.authorid0000-0002-0675-1839en_US
dc.identifier.volume129en_US
dc.identifier.issue4en_US
dc.identifier.startpage363en_US
dc.identifier.endpage368en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1080/00207454.2018.1538141en_US


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