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dc.contributor.authorMataracı Kara, Emel
dc.contributor.authorYılmaz, Mesut
dc.contributor.authorÖzbek Çelik, Berna
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:32Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:32Z
dc.date.issued2019en_US
dc.identifier.citationMataracı Kara, E., Yılmaz, M. ve Özbek Çelik, B. (2019). In vitro activities of ceftazidime/avibactam alone or in combination with antibiotics against multidrug-resistant Acinetobacter baumannii isolates. Journal of Global Antimicrobial Resistance, 17, 137-141. https://dx.doi.org/10.1016/j.jgar.2018.12.004en_US
dc.identifier.issn2213-7165
dc.identifier.issn2213-7173
dc.identifier.urihttps://dx.doi.org/10.1016/j.jgar.2018.12.004
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1626
dc.descriptionWOS: 000471951900029en_US
dc.descriptionPubMed ID: 30576787en_US
dc.description.abstractObjectives: Infections caused by multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) are a growing problem because of the limited options for treatment. The number of antimicrobials that are currently being developed is still insufficient to control this global threat. Combination therapies of antibiotics with different antimicrobial mechanisms have been proposed as the best options for treating MDR A. baumannii infections. The objective of this study was to investigate the in-vitro effectiveness of ceftazidime/avibactam alone or in combination with antibiotics against MDR A. baumannii isolates using time-kill assays. Methods: Forty clinical MDR strains were screened, and minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of ceftazidime/avibactam, colistin, levofloxacin, meropenem, tigecycline, and tobramycin were determined by microbroth dilution method. The in-vitro synergistic activities of ceftazidime/avibactam with antibiotic combinations were determined by time-kill assays at 1 x MIC and 4 x MIC against five MDR A. baumannii isolates. Results: Based on MIC results, all isolates of A. baumannii were resistant to ceftazidime/avibactam, except for AB-5. All isolates were found to be resistant to meropenem and levofloxacin. At 4 x MIC, all of the tested antibiotics showed bactericidal effect (>= 3 log (10) killing). The synergistic activities of ceftazidime/avibactam + colistin, ceftazidime/avibactam + tobramycin and ceftazidime/avibactam + tigecycline combinations at 1 x MIC were observed against studied 5/5, 4/5 and 4/5 strains, respectively. Furthermore, all of the tested combinations at 4 x MIC were additive at 24 h. No antagonism was observed. Conclusions: The findings of this study suggest that a significant bactericidal effect was seen with all tested combinations. These findings present significant implications for antibiotic choice for the treatment of infections caused by MDR A. baumannii.en_US
dc.description.sponsorshipResearch Fund of the University of Istanbul (Istanbul, Turkey) [21897]en_US
dc.description.sponsorshipThis work was supported by a grant from the Research Fund of the University of Istanbul (Istanbul, Turkey). Project number: 21897.en_US
dc.language.isoengen_US
dc.publisherElsevier Science Ltden_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectCeftazidime/Avibactamen_US
dc.subjectCombinationen_US
dc.subjectBeta-Lactam Inhibitorsen_US
dc.subjectGram-Negativeen_US
dc.subjectSynergyen_US
dc.titleIn vitro activities of ceftazidime/avibactam alone or in combination with antibiotics against multidrug-resistant Acinetobacter baumannii isolatesen_US
dc.typearticleen_US
dc.relation.journalJournal of Global Antimicrobial Resistanceen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalıen_US
dc.authorid0000-0001-8022-7325en_US
dc.identifier.volume17en_US
dc.identifier.startpage137en_US
dc.identifier.endpage141en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.jgar.2018.12.004en_US


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