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dc.contributor.authorAtasoy, Deniz
dc.contributor.authorSternson, Scott M.
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:38:24Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:38:24Z
dc.date.issued2016en_US
dc.identifier.citationAtasoy, D. ve Sternson, S. M. (2016). Functional and anatomical dissection of feeding circuits. Neuroendocrinology of Appetite içinde (112-133. ss.). https://dx.doi.org/10.1002/9781118839317.ch6en_US
dc.identifier.isbn9781118839317 -- 9781118839324
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1590
dc.identifier.urihttps://dx.doi.org/10.1002/9781118839317.ch6
dc.description.abstractThis chapter reviews the application of new genetically encoded tools in feeding circuits that regulate appetite. Rapid activation and inhibition of agouti related peptide (AgRP) neurons conclusively established a causal role for rapid control of food intake. Chemogenetic activation of AgRP neurons using hM3Dq avoids the invasive protocols required for ChR2 activation. ChR2 distributes into axons, and selective optogenetic activation of AgRP neuron axon projection fields in distinct brain areas was used to examine their individual contribution to feeding behavior. Some of the brain areas targeted by AgRP neuron axon projections have been examined further for cell type specific control of appetite. Rodents with bed nucleus of stria terminalis (BNST) lesions show hyperphagia and obesity, indicating that reduced BNST output promotes feeding. pro-opiomelanocortin (POMC) neurons regulate feeding over longer timescales. parabrachial nucleus (PBN) neurons have a powerful inhibitory role on food intake, but their inhibition does not strongly elevate food intake.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgouti Related Peptide Neuronsen_US
dc.subjectAppetite Regulationen_US
dc.subjectBed Nucleus of Stria Terminalisen_US
dc.subjectChemogenetic Toolsen_US
dc.subjectFeeding Circuitsen_US
dc.subjectObesityen_US
dc.subjectOptogenetic Toolsen_US
dc.subjectParabrachial Nucleus Neuronsen_US
dc.subjectPro-Opiomelanocortin Neuronsen_US
dc.titleFunctional and anatomical dissection of feeding circuitsen_US
dc.typebookParten_US
dc.relation.ispartofNeuroendocrinology of Appetiteen_US
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-3325-8820en_US
dc.identifier.startpage112en_US
dc.identifier.endpage133en_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.identifier.doi10.1002/9781118839317.ch6en_US


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