Yayın tarihi için Biyomedikal Mühendisliği ve Biyoenformatik listeleme
Toplam kayıt 17, listelenen: 1-17
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Development of a histotripsy agent using host-guest interaction
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2017)Histotripsy is a mechanical cell ablation technique, which works on the mechanism of acoustic cavitation using microsecond-long, high-frequency ultrasound (US) pulses that can generate a bubble cloud (cavitation) using the ... -
Finite element analysis of cervical spine & finite element modeling of knee joint
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2017)Finite Element (FE) analysis allows predicting the behavior of real life systems in controlled environment. In the recent decades, FE modeling has gained significant attention of the medical industry as well. There is no ... -
Design of a voltammetry system for in vivo measurement of dopamine concentration
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2018)Dopamine has a critical role in motor control, motor learning, reinforcement learning, cognition, attention and motivation. Consequently, the physiology of the dopaminergic system is an important and highly active research ... -
An integrative gene-expression analysis of axolotl limb wound healing and regeneration
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2019)Axolotl is a member of the urodele amphibians that exhibits extraordinary regenerative and scarless wound healing capabilities, fully restoring a lost limb as well as efficiently healing a damaged one. Axolotl has recently ... -
Computational fluid dynamics analysis in pre-surgery planning for congenital heart defect repairs
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2019)The treatment of complex congenital heart diseases (CHD) requires a careful patient-specific approach and surgical correction plan. In this thesis, a large radiological database was created to provide supportive information ... -
Neuroprotective effects of curcumin-loaded emulsomes on laser-induced axotomy modelled primary hippocampal neurons
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2019)As reported by WHO, it has been anticipated that neurodegenerative diseases will be the second cause of death following the cardiovascular diseases by 2040. A polyphenol isolated from the rhizomes of turmeric called curcumin ... -
Aloe-vera extract as drag reducing polymer to regulate blood pressure and tissue oxygenation during hemorrhagic shock
(İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2019)Hemorrhagic shock is one of the most important causes of death among traumatized patients. The common treatment is replacing lost volume with colloids or crystalloids, which should never be overloaded to return blood ... -
In silico phosphorylation-independent activation of arrestin-3 protein by means of small molecules
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2019)G protein-coupled receptors (GPCRs) are responsible for communication of the cell with its surroundings. Upon ligand binding, a set of conformational changes occurs at the GPCR, which triggers activation and dissociation ... -
Integrative analysis of axolotl gene expression data from regenerative and wound healing limb tissues
(Nature Research, 2019)Axolotl (Ambystoma mexicanum) is a urodele amphibian endowed with remarkable regenerative capacities manifested in scarless wound healing and restoration of amputated limbs, which makes it a powerful experimental model for ... -
Combined network analysis and molecular dynamics simulations study for characterization of prevalent somatic mutations in breast cancer: Sf3b1 case study
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2020)Breast cancer has the highest incidence and mortality rates among women. The etiology of the disease has remained elusive because of complex interactions among various factors. The somatic mutations are one of such factors ... -
Evaluation of dopamine signaling in the rat ventromedial striatum for varying reward proximity
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2020)Dopaminergic neurons play an important role in reward-mediated learning and motor control. In this work, we studied the transient changes in dopamine concentration in the ventromedial striatum (VMS) or nucleus accumbens ... -
Development of EPPT1 targeted biocompatible drug delivery system and investigation of its anticancer activity
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2020)Recently, the superior properties of graphene to other biomaterials have made graphene an indispensable and unique material for anticancer drug delivery research, gene and peptide transport. On the other hand, the undeniable ... -
Design of a multichannel electrophysiology amplifier and a rat behavioral paradigm for motor neuroprosthetic control
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2020)The development in brain-machine interfaces (BMIs) not only provided efficient solutions for the control of neuroprosthetic devices, aiming to recover motor functions lost to disease or injury, but also allows the researchers ... -
Investigation of the candidate tumor suppressor gene CTCF using multi-omics data mining
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2021)CCCTC binding factor (CTCF) is a vertebrate, 11-zinc-finger protein. This ubiquitously expressed multifunctional transcription factor can bind to a myriad of target sites in the genome. It is involved, among others, in ... -
Computational investigation and modulation of structural and functional properties of proteins for therapeutic purposes
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2021)Proteins are dynamic molecules which undergo certain conformational changes to perform specific functions when needed in the cell. To have a holistic understanding of the conformational ensemble they attain one needs to ... -
Machine learning-based analysis of glioma grades reveals co-enrichment
(MDPI, 2022)Gliomas develop and grow in the brain and central nervous system. Examining glioma grading processes is valuable for improving therapeutic challenges. One of the most extensive repositories storing transcriptomics data for ... -
Finite element spine models and spinal instruments: A review
(World Scientific Publishing Co Pte Ltd, 2022)There is considerable biomechanics literature on finite element modeling and analysis of the spine. To accurately mimic the biomechanical behavior of the vertebral column, a generated computational model has to include ...
