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dc.contributor.authorTay, Funda
dc.contributor.authorErkan, Celal
dc.contributor.authorYılmaz Sarıözlü, Nalan
dc.contributor.authorErgene. Emel
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:37:28Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:37:28Z
dc.date.issued2017en_US
dc.identifier.citationTay, F., Erkan, C., Yılmaz Sarıözlü, N., Ergene, E. ve Demirayak, Ş. (2017). Synthesis, antimicrobial and anticancer activities of some naphthylthiazolylamine derivatives. Biomedical Research-India, 28(6), 2696-2703.en_US
dc.identifier.issn0970-938X
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1410
dc.description13th International Symposium on Wireless Communication Systems, ISWCS 2016en_US
dc.description20 September 2016 through 23 September 2016en_US
dc.description124401en_US
dc.description.abstractNew 4-naphthyl-2-aminothiazole derivatives were synthesized. The newly synthesized compounds were screened for their in vitro antimicrobial and anticancer activities. The results indicated that compound 5b namely 2-(4-methylpiperidine-1-yl)-4-(naphthalene-2-yl) thiazole exhibited highest MIC value (62.5 µg/ml) against P. aeruginosa in the tested microorganisms. This compound showed equipotent antifungal effect on C. albicans and C. glabrata as compared with ketoconazole. Compounds 4c, 4d, 5a and 5f showed remarkably antifungal activity against C. albicans. In addition, anticancer activity and cytotoxicity studies were also carried out in Hep-G2 and A549 cell lines to examine the ability of inhibiting the cell growth for 4a-4f and 5a-5f compounds. The cell viability and anticancer activity were determined by MTT assay. 4a-4f compounds has led to an increase in cell proliferation in both cell lines (Hep-G2 and A549 cells), unlike 5a-5f series showed a weak anticancer activity.en_US
dc.description.sponsorshipEskisehir Osmangazi Universityen_US
dc.language.isoengen_US
dc.publisherScientific Publishers of Indiaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectCytotoxicityen_US
dc.subjectMTT Assayen_US
dc.subjectNaphthaleneen_US
dc.subjectThiazoleen_US
dc.titleSynthesis, antimicrobial and anticancer activities of some naphthylthiazolylamine derivativesen_US
dc.typearticleen_US
dc.relation.ispartofBiomedical Research-Indiaen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalıen_US
dc.authorid0000-0002-0841-1299en_US
dc.identifier.volume28en_US
dc.identifier.issue6en_US
dc.identifier.startpage2696en_US
dc.identifier.endpage2703en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.wosqualityQ4en_US
dc.identifier.scopusqualityQ4en_US


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