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dc.contributor.authorAdeviye Erşahin, Aynur
dc.contributor.authorAcet, Mustafa
dc.contributor.authorErşahin, Suat Suphan
dc.contributor.authorAcet, Tuba
dc.contributor.authorYardım, Meltem
dc.contributor.authorKenanoğlu, Ömer
dc.contributor.authorAydın, Süleyman
dc.identifier.citationAdeviye Erşahin, A., Acet, M., Erşahin, S. S., Acet, T., Yardım, M., Kenanoğlu, Ö. ... Aydın, S. (2017). Follicular fluid cerebellin and betatrophin regulate the metabolic functions of growing follicles in polycystic ovary syndrome. Clinical and Experimental Reproductive Medicine, 44(1), 33-39.
dc.description.abstractObjective The aim of this study was to assess the changes of follicular fluid (FF) and serum levels of cerebellin precursor protein 1 (cbln1) and betatrophin in patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) with a gonadotropin-releasing hormone (GnRH) antagonist protocol. Methods Twenty infertile women with PCOS and 20 control women diagnosed as poor responders undergoing ovarian stimulation with a GnRH antagonist were included. Blood samples were obtained during ovum pick-up. Follicular fluid from a dominant follicle was collected from the subjects. Using enzyme-linked immunosorbent assays, FF and serum levels of cbln1 and betatrophin were measured in both groups of participants. Metabolic and hormonal parameters were also determined and correlated with each other. Results Both groups of women had similar serum and FF betatrophin levels (55.0±8.9 ng/mL vs. 53.1±10.3 ng/mL, p=0.11). The serum and FF betatrophin levels of poor responders were found to be similar (49.9±5.9 ng/mL vs. 48.9±10.7 ng/mL, p=0.22). Conversely, the FF cbln1 levels of PCOS women were found to be significantly higher than the serum cbln1 levels (589.1±147.6 ng/L vs. 531.7±74.3 ng/L, p < 0.02). The FF cbln1 levels of control participants without PCOS were significantly higher than their serum cbln1 levels (599.3±211.5 ng/L vs. 525.3±87.0 ng/L, p=0.01). Positive correlations were detected among body mass index, insulin resistance, serum insulin, total testosterone, and betatrophin levels in the PCOS group. Conclusion Follicular fluid betatrophin and cbln1 concentrations may play a pivotal role on follicular growth in PCOS subjects undergoing IVF/ICSI with an antagonist protocol.en_US
dc.publisherKorean Society for Reproductive Medicineen_US
dc.rightsAttribution-NonCommercial 4.0 International*
dc.subjectAntagonist Protocolen_US
dc.subjectFollicular Fluiden_US
dc.subjectIn Vitro Fertilizationen_US
dc.subjectIntracytoplasmic Sperm Injectionen_US
dc.subjectPolycystic Ovary Syndromeen_US
dc.titleFollicular fluid cerebellin and betatrophin regulate the metabolic functions of growing follicles in polycystic ovary syndromeen_US
dc.relation.journalClinical and Experimental Reproductive Medicineen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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