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dc.contributor.authorBabür Güler, Gamze
dc.contributor.authorGüler, Ekrem
dc.contributor.authorHatipoğlu, Suzan
dc.contributor.authorGüneş, Hacı Murat
dc.contributor.authorGeçmen, Çetin
dc.contributor.authorDemir, Gültekin Günhan
dc.contributor.authorBarutçu, İrfan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:37:04Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:37:04Z
dc.date.issued2016en_US
dc.identifier.citationBabür Güler, G., Güler, E., Hatipoğlu, S., Güneş, H. M., Geçmen, Ç., Demir, G. G. ... Barutçu, İ. (2016). Assessment of 25-OH vitamin D levels and abnormal blood pressure response in female patients with cardiac syndrome X. Anatolian Journal of Cardiology, 16(12), 961-966.en_US
dc.identifier.issn2149-2263
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1323
dc.identifier.urihttps://dx.doi.org/10.14744/AnatolJCardiol.2016.6862
dc.description.abstractObjective: Vitamin D deficiency is associated with coronary artery disease, hypertension, heart failure, endothelial dysfunction, and metabolic syndrome. The pathophysiology of cardiac syndrome X (CSX) involves many pathways that are influenced by vitamin D levels. This study aimed to investigate the relationship between vitamin D deficiency and abnormal blood pressure response to exercise in patients with CSX. Methods: This was a cross-sectional and observational study. Fifty females with normal epicardial coronary arteries who presented with typical symptoms of rest or effort angina and 41 healthy age-matched female controls, were included. Patients with cardiomyopathy, severe valvular disease, congenital heart disease, and left ventricular hypertrophy were excluded. All patients underwent stress electrocardiography examination and 25-hydroxy (OH) vitamin D level measurements. Results: Levels of 25-OH vitamin D were significantly lower in CSX patients (9.8±7.3 ng/mL vs. 18.1±7.9 ng/mL; p<0.001). Systolic blood pressure (SBP) (188±15 mm Hg vs. 179±17 mm Hg; p=0.013) and diastolic blood pressure (DBP) (98±9 mm Hg vs. 88±9 mm Hg; p<0.001) during peak exercise were higher in CSX patients. Levels of 25-OH vitamin D were negatively correlated with peak SBP (r=–0.310, p=0.004) and peak DBP (r=–0.535, p<0.001) during exercise. To discard the multicollinearity problem, two different models were used for multivariate analyses. In the first model, metabolic equivalents (METs) (p=0.003) and 25-OH vitamin D levels (p=0.001) were independent predictors. METs (p=0.007), 25-OH vitamin D levels (p=0.008), and peak DBP were determined as independent predictors in the second multivariate model. Conclusion: In patients with CSX, 25-OH vitamin D levels were lower than those in controls; moreover, 25-OH vitamin D deficiency was also associated with higher levels of peak DBP during exercise.en_US
dc.language.isoengen_US
dc.publisherTurkish Society of Cardiologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject25-OH Vitamin Den_US
dc.subjectAbnormal Blood Pressure Responseen_US
dc.subjectCardiac Syndrome Xen_US
dc.titleAssessment of 25-OH vitamin D levels and abnormal blood pressure response in female patients with cardiac syndrome Xen_US
dc.typearticleen_US
dc.relation.journalAnatolian Journal of Cardiologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-4607-5724en_US
dc.authorid0000-0001-9975-5507en_US
dc.identifier.volume16en_US
dc.identifier.issue12en_US
dc.identifier.startpage961en_US
dc.identifier.endpage966en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.14744/AnatolJCardiol.2016.6862en_US


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