dc.contributor.author | Elmas, Bahri | |
dc.contributor.author | Karacan, Mehmet | |
dc.contributor.author | Dervişoğlu, Pınar | |
dc.contributor.author | Kösecik, Mustafa | |
dc.contributor.author | İşgüven, Şükriye Pınar | |
dc.contributor.author | Bal, Ceylan | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:37:03Z | |
dc.date.available | 10.07.201910:49:14 | |
dc.date.available | 2019-07-10T19:37:03Z | |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | Elmas, B., Karacan, M., Dervişoğlu, P., Kösecik, M., İşgüven, Ş. P. ve Bal, C. (2017). Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers. Anatolian Journal of Cardiology, 18(5), 361-369. https://dx.doi.org/10.14744/AnatolJCardiol.2017.7740 | en_US |
dc.identifier.issn | 2149-2263 | |
dc.identifier.issn | 2149-2271 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/1320 | |
dc.identifier.uri | https://dx.doi.org/10.14744/AnatolJCardiol.2017.7740 | |
dc.description.abstract | Objective: Childhood obesity is an important cause of cardiovascular risk with chronic inflammation. Oxidative stress may contribute to the pathogenesis of obesity-related cardiovascular pathologies. We aimed to evaluate thiol/disulphide homeostasis as a novel and sensitive marker of oxidative stress and to evaluate its relationship with some inflammatory and cardiovascular markers in obese children. Methods: In this case-controlled study, 65 children with exogenous obesity and 64 healthy children, as a control group, were included. In both groups, thiol/disulphide homeostasis parameters and inflammatory (white blood cells, platelets, mean corpuscular volume, neutrophil/lympho-cyte ratio, and high-sensitivity C-reactive protein) and cardiovascular (epicardial adipose tissue thickness and left ventricular mass index) markers were studied. Correlation analyses of thiol/disulphide homeostasis parameters with body mass index standard deviation scores (BMI SDS) and inflammatory and cardiovascular markers were performed. Receiver-operating characteristic analysis was performed to determine the sensitivity, specificity, and optimal cut-off values of thiol/disulphide homeostasis parameters. Results: Native thiol, total thiol, and native thiol/total thiol ratios (antioxidant parameters) were lower (p<0.05) and disulphide/native thiol and disulphide/total thiol ratios (oxidant parameters) were higher in the obese group than in the control group (p<0.01). A positive correlation of oxidant parameters with BMI SDS and inflammatory markers was found. However, a negative correlation of antioxidant parameters with BMI SDS and inflammatory markers was found. The specificities of disulphide/native thiol and disulphide/total thiol ratios were higher in the obese group. Conclusion: The impairment in thiol/disulphide homeostasis, which is indicative of oxidative stress, is associated with inflammation in obesity. In addition, cardiovascular involvement may also contribute to this impairment. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Turkish Society of Cardiology | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Cardiovascular Risk | en_US |
dc.subject | Children | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Obesity | en_US |
dc.subject | Oxidative Stress | en_US |
dc.subject | Thiol/Disulphide Homeostasis | en_US |
dc.title | Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Anatolian Journal of Cardiology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-4375-2881 | en_US |
dc.identifier.volume | 18 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 361 | en_US |
dc.identifier.endpage | 369 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.14744/AnatolJCardiol.2017.7740 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.scopusquality | Q3 | en_US |