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dc.contributor.authorÖtünçtemur, Alper
dc.contributor.authorÖzbek, Emin
dc.contributor.authorŞahin, Süleyman
dc.contributor.authorÖzcan, Levent
dc.contributor.authorDursun, Murat
dc.contributor.authorPolat, Emre Can
dc.contributor.authorÇekmen, Mustafa Baki
dc.contributor.authorÖzsoy, Özgür Doğa
dc.contributor.authorErkoç, Mustafa
dc.contributor.authorDaniş, Eyüp
dc.contributor.authorBozkurt, Muammer
dc.identifier.citationÖtünçtemur A., Özbek E., Şahin S., Özcan L., Dursun M., Polat E. C. ... Bozkurt M. (2016). Low serum insulin-like growth factor-1 in patients with erectile dysfunction. Basic and Clinical Andrology, 26.
dc.description.abstractObjective: Endothelial dysfunction and microvascular damage play a crurical role in the pathogenesis of erectile dysfunction (ED). Insulin-like growth factor-1 (IGF-1) is one of the growth factors that have a wide range of biologic effects. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues. The purpose of the current study was to determine the association between IGF-1 levels and ED. Materials and methods: All men were evaluated for ED and divided into two groups: 80 patients suffering from ED for > 1 year and 80 subjects without ED were enrolled as a control group in this study. Diagnosis of ED was based on the International Index of Erectile Function Score-5. IGF-1 levels were measured in serum by an automated chemiluminescence immunoassay. The relationship between IGF-1 levels and ED scores in patients was statistically evaluated. Results: The mean age of patients in ED group was 60.4 ± 11.3 years and 55.4 ± 9.6 in control group. The plasma IGF-1 levels were significantly lower in ED than in control group (96.5 ± 38.3 and 132.5 ± 53.3 ng/ mL, respectively, P < 0.001). The IGF-1 levels were positively correlated with ED score (r = 0.623, P < 0.01). Conclusion: In this study serum IGF-1 levels were found to be associated with endothelial dysfunction that predicts ED. Serum IGF-1 level appears to be a specific predictor of ED, and it might be used in early prediction of ED in male population.en_US
dc.publisherBioMed Central Ltd.en_US
dc.rightsAttribution 4.0 International*
dc.subjectEndothelial Dysfunctionen_US
dc.subjectErectile Dysfunctionen_US
dc.subjectInsulin-Like Growth Factor-1en_US
dc.subjectInternational Index of Erectile Function Score-5en_US
dc.titleLow serum insulin-like growth factor-1 in patients with erectile dysfunctionen_US
dc.relation.journalBasic and Clinical Andrologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalıen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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