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dc.contributor.authorÖtünçtemur, Alper
dc.contributor.authorÖzbek, Emin
dc.contributor.authorŞahin, Süleyman
dc.contributor.authorÖzcan, Levent
dc.contributor.authorDursun, Murat
dc.contributor.authorPolat, Emre Can
dc.contributor.authorÇekmen, Mustafa Baki
dc.contributor.authorÖzsoy, Özgür Doğa
dc.contributor.authorErkoç, Mustafa
dc.contributor.authorDaniş, Eyüp
dc.contributor.authorBozkurt, Muammer
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:56Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:56Z
dc.date.issued2016en_US
dc.identifier.citationÖtünçtemur A., Özbek E., Şahin S., Özcan L., Dursun M., Polat E. C. ... Bozkurt M. (2016). Low serum insulin-like growth factor-1 in patients with erectile dysfunction. Basic and Clinical Andrology, 26. https://dx.doi.org/10.1186/s12610-015-0028-xen_US
dc.identifier.issn2051-4190
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1291
dc.identifier.urihttps://dx.doi.org/10.1186/s12610-015-0028-x
dc.description.abstractObjective: Endothelial dysfunction and microvascular damage play a crurical role in the pathogenesis of erectile dysfunction (ED). Insulin-like growth factor-1 (IGF-1) is one of the growth factors that have a wide range of biologic effects. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues. The purpose of the current study was to determine the association between IGF-1 levels and ED. Materials and methods: All men were evaluated for ED and divided into two groups: 80 patients suffering from ED for > 1 year and 80 subjects without ED were enrolled as a control group in this study. Diagnosis of ED was based on the International Index of Erectile Function Score-5. IGF-1 levels were measured in serum by an automated chemiluminescence immunoassay. The relationship between IGF-1 levels and ED scores in patients was statistically evaluated. Results: The mean age of patients in ED group was 60.4 ± 11.3 years and 55.4 ± 9.6 in control group. The plasma IGF-1 levels were significantly lower in ED than in control group (96.5 ± 38.3 and 132.5 ± 53.3 ng/ mL, respectively, P < 0.001). The IGF-1 levels were positively correlated with ED score (r = 0.623, P < 0.01). Conclusion: In this study serum IGF-1 levels were found to be associated with endothelial dysfunction that predicts ED. Serum IGF-1 level appears to be a specific predictor of ED, and it might be used in early prediction of ED in male population.en_US
dc.language.isoengen_US
dc.publisherBioMed Central Ltd.en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectEndothelial Dysfunctionen_US
dc.subjectErectile Dysfunctionen_US
dc.subjectInsulin-Like Growth Factor-1en_US
dc.subjectInternational Index of Erectile Function Score-5en_US
dc.titleLow serum insulin-like growth factor-1 in patients with erectile dysfunctionen_US
dc.typearticleen_US
dc.relation.journalBasic and Clinical Andrologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalıen_US
dc.authorid0000-0001-5254-2563en_US
dc.identifier.volume26en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1186/s12610-015-0028-xen_US


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