Pea3 transcription factor promotes neurite outgrowth
Savaşan Soğut, Melis
Aksan Kurnaz, Işıl
MetadataShow full item record
CitationKandemir, B., Çağlayan, B., Hausott, B., Erdoğan, B., Dağ, U., Demir, Ö. ... Aksan Kurnaz, I. (2014). Pea3 transcription factor promotes neurite outgrowth. Frontiers in Molecular Neuroscience, 7, 11-14. https://dx.doi.org/10.3389/fnmol.2014.00059
Pea3 subfamily of E-twenty six transcription factors consist of three major -exhibit branching morphogenesis, the function of Pea3 family in nervous system development and regeneration is only beginning to unfold. In this study, we provide evidence that Pea3 can directs neurite extension and axonal outgrowth in different model systems, and that Serine 90 is important for this function. We have also identified neurofilament-L and neurofilament-M as two putative novel targets for Pea3.