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dc.contributor.authorPençe, Sadrettin
dc.contributor.authorİkizceli, İbrahim
dc.contributor.authorÖzbek, Emin
dc.contributor.authorTiryakioğlu, Necip Ozan
dc.contributor.authorEren, Hilal
dc.contributor.authorPolat, Emre Can
dc.contributor.authorPençe, Halime Hanım
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:33Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:33Z
dc.date.issued2014en_US
dc.identifier.citationPençe, S., İkizceli, İ., Özbek, E., Tiryakioğlu, N. O., Eren, H., Polat, E. C. ... Pençe H. H. (2014). Low oxalobacter formigenes colonization is associated with reduced bone mineral density in urinary stone forming patients. Current Urology, 8(4), 189-193. https://dx.doi.org/10.1159/000365715en_US
dc.identifier.issn1661-7649
dc.identifier.urihttps://dx.doi.org/10.1159/000365715
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1193
dc.description.abstractIntroduction: Lower bone mineral density (BMD) and reduced Oxalobacter formigenes colonization are common findings in urolithiasis patients. But none of the studies conducted investigated the relationship between decreased bone mineral density and reduced Oxalobacter colonization. Here we evaluated the relation between BMD and O. formigenes colonization in urolithiasis patients. Materials and Methods: 50 stone formers (48.9 ± 11.9 years) and 50 control (47.2 ± 13.4 years) adult male subjects were included in the study. Alterations in O. formigenes colonization were determined as absolute O. formigenes count from fecal samples by real time polymerase chain reaction using species specific primers. BMD was evaluated from t- and z- scores calculated by using dual energy absorptiometry in the total femoral neck and lumbar spine (L2-L4). Results: Low BMD was observed in 18 (36%) urinary stone forming patients and in 7 (14%) control subjects in the lumbar area (p < 0.05). The mean O. formigenes count in stone formers and control subjects were 19,257 (5,791 ± 1,117.93) and 143,850 (2,815,725 ± 3,946,044.7) (p < 0.05) respectively. We observed a correlation between decreased lumbar BMD and O. formigenes colonization and testosterone levels in stone formers. Our results indicated that diminished O. formigenes colonization in the gut of urinary stone forming subjects was associated with reduced BMD.en_US
dc.language.isoengen_US
dc.publisherS. Karger AGen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone Mineral Densityen_US
dc.subjectOxalate Degradationen_US
dc.subjectOxalobacter Formigenesen_US
dc.subjectUrolithiasisen_US
dc.titleLow oxalobacter formigenes colonization is associated with reduced bone mineral density in urinary stone forming patientsen_US
dc.typearticleen_US
dc.relation.ispartofCurrent Urologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.identifier.volume8en_US
dc.identifier.issue4en_US
dc.identifier.startpage189en_US
dc.identifier.endpage193en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1159/000365715en_US
dc.identifier.scopusqualityQ3en_US


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