Bölüm "İstanbul Medipol Üniversitesi, Fen Bilimleri Enstitüsü, Biyomedikal Mühendisliği ve Biyoenformatik Ana Bilim Dalı" Tez Koleksiyonu için listeleme
Toplam kayıt 20, listelenen: 1-20
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Aloe-vera extract as drag reducing polymer to regulate blood pressure and tissue oxygenation during hemorrhagic shock
(İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2019)Hemorrhagic shock is one of the most important causes of death among traumatized patients. The common treatment is replacing lost volume with colloids or crystalloids, which should never be overloaded to return blood ... -
Bioconjugated β-cyclodextrin-perfluorohexane nanocone clusters as functional agents for nanoparticle mediated histotripsy
(İstanbul Medipol Üniversitesi, Fen Bilimleri Enstitüsü, 2022)Nanocone clusters (NCC) as new generation agent of nanoparticle mediated histotripsy (NMH) successfully addressed all the limitations of previously designed nanodroplets (NDs). NCC can be obtained by simply mixing of ... -
Combined network analysis and molecular dynamics simulations study for characterization of prevalent somatic mutations in breast cancer: Sf3b1 case study
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2020)Breast cancer has the highest incidence and mortality rates among women. The etiology of the disease has remained elusive because of complex interactions among various factors. The somatic mutations are one of such factors ... -
Computational fluid dynamics analysis in pre-surgery planning for congenital heart defect repairs
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2019)The treatment of complex congenital heart diseases (CHD) requires a careful patient-specific approach and surgical correction plan. In this thesis, a large radiological database was created to provide supportive information ... -
Computational investigation and modulation of structural and functional properties of proteins for therapeutic purposes
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2021)Proteins are dynamic molecules which undergo certain conformational changes to perform specific functions when needed in the cell. To have a holistic understanding of the conformational ensemble they attain one needs to ... -
Design of a multichannel electrophysiology amplifier and a rat behavioral paradigm for motor neuroprosthetic control
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2020)The development in brain-machine interfaces (BMIs) not only provided efficient solutions for the control of neuroprosthetic devices, aiming to recover motor functions lost to disease or injury, but also allows the researchers ... -
Design of a voltammetry system for in vivo measurement of dopamine concentration
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2018)Dopamine has a critical role in motor control, motor learning, reinforcement learning, cognition, attention and motivation. Consequently, the physiology of the dopaminergic system is an important and highly active research ... -
Development of EPPT1 targeted biocompatible drug delivery system and investigation of its anticancer activity
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2020)Recently, the superior properties of graphene to other biomaterials have made graphene an indispensable and unique material for anticancer drug delivery research, gene and peptide transport. On the other hand, the undeniable ... -
Development of a histotripsy agent using host-guest interaction
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2017)Histotripsy is a mechanical cell ablation technique, which works on the mechanism of acoustic cavitation using microsecond-long, high-frequency ultrasound (US) pulses that can generate a bubble cloud (cavitation) using the ... -
Development of anti-cancer nanoformulations by incorporation of water-insoluble natural bioactive agents into lipid-based drug delivery systems
(İstanbul Medipol Üniversitesi, Fen Bilimleri Enstitüsü, 2022)Broccoli is a well-known and highly consumed vegetable around the world, it falls into the cruciferous category, which is proven to be effective against breast, skin, and prostate cancers. This anti-cancer property stems ... -
The development of multifunctional nanoplatforms for targeted dual drug delivery
(İstanbul Medipol Üniversitesi, Fen Bilimleri Enstitüsü, 2022)The research on the use of graphene (G) in biological applications as a drug and gene carrier has increased exponentially simply due to its superior properties as a nanomaterial. On the other hand, many research studies ... -
Evaluation of dopamine signaling in the rat ventromedial striatum for varying reward proximity
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2020)Dopaminergic neurons play an important role in reward-mediated learning and motor control. In this work, we studied the transient changes in dopamine concentration in the ventromedial striatum (VMS) or nucleus accumbens ... -
Finite element analysis of cervical spine & finite element modeling of knee joint
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2017)Finite Element (FE) analysis allows predicting the behavior of real life systems in controlled environment. In the recent decades, FE modeling has gained significant attention of the medical industry as well. There is no ... -
In silico phosphorylation-independent activation of arrestin-3 protein by means of small molecules
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2019)G protein-coupled receptors (GPCRs) are responsible for communication of the cell with its surroundings. Upon ligand binding, a set of conformational changes occurs at the GPCR, which triggers activation and dissociation ... -
An integrative gene-expression analysis of axolotl limb wound healing and regeneration
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2019)Axolotl is a member of the urodele amphibians that exhibits extraordinary regenerative and scarless wound healing capabilities, fully restoring a lost limb as well as efficiently healing a damaged one. Axolotl has recently ... -
Investigation of the candidate tumor suppressor gene CTCF using multi-omics data mining
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2021)CCCTC binding factor (CTCF) is a vertebrate, 11-zinc-finger protein. This ubiquitously expressed multifunctional transcription factor can bind to a myriad of target sites in the genome. It is involved, among others, in ... -
Mechanical analysis of spinal implants in patients with adolescent idiopathic scoliosis
(İstanbul Medipol Üniversitesi, Fen Bilimleri Enstitüsü, 2022)Spinal instruments have been employed to facilitate the fusion processes in spinal surgeries and correct the misalignment of the spine. In spinal fusion, the compressive biomechanical forces applied to the models also ... -
Neuroprotective effects of curcumin-loaded emulsomes on laser-induced axotomy modelled primary hippocampal neurons
(İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2019)As reported by WHO, it has been anticipated that neurodegenerative diseases will be the second cause of death following the cardiovascular diseases by 2040. A polyphenol isolated from the rhizomes of turmeric called curcumin ... -
A new rodent behavioral paradigm for studying closed-loop cursor control
(İstanbul Medipol Üniversitesi, Fen Bilimleri Enstitüsü, 2022)Control of cursor on a PC monitor using a joystick is a standard paradigm to study the neural mechanisms involved in motor skill learning in human and non-human primates. This paradigm is also commonly used in non-human ... -
Plasmonic biosensor design and alternative plasmonic materials
(İstanbul Medipol Üniversitesi, Fen Bilimleri Enstitüsü, 2022)Light-matter interaction is the one of the most important and studied topic in time dependent quantum mechanic especially for description of spectroscopy. Light matter interaction can be described in two ways. First one ...