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Computational investigation and modulation of structural and functional properties of proteins for therapeutic purposes
Mansoor, Samman (İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2021)Proteins are dynamic molecules which undergo certain conformational changes to perform specific functions when needed in the cell. To have a holistic understanding of the conformational ensemble they attain one needs to ... -
In silico phosphorylation-independent activation of arrestin-3 protein by means of small molecules
Kurt, Mehmet Hanifi (İstanbul Medipol Üniversitesi Fen Bilimleri Enstitüsü, 2019)G protein-coupled receptors (GPCRs) are responsible for communication of the cell with its surroundings. Upon ligand binding, a set of conformational changes occurs at the GPCR, which triggers activation and dissociation ...