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dc.contributor.authorCantürk, Emir
dc.contributor.authorÇakal, Beytullah
dc.contributor.authorKaraca, Oğuz
dc.contributor.authorOmaygenç, Onur
dc.contributor.authorSalihi, Salih
dc.contributor.authorÖzyüksel, Arda
dc.contributor.authorAkçevin, Atıf
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:18Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:18Z
dc.date.issued2017en_US
dc.identifier.citationCantürk, E., Çakal, B., Karaca, O., Omaygenç, O., Salihi, S., Özyüksel, A. ... Akçevin, A. (2017). Changes in aortic pulse wave velocity and the predictors of improvement in arterial stiffness following aortic valve replacement. Annals of Thoracic and Cardiovascular Surgery, 23(5), 248-255. https://dx.doi.org/10.5761/atcs.oa.17-00062en_US
dc.identifier.issn1341-1098
dc.identifier.issn2186-1005
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1123
dc.identifier.urihttps://dx.doi.org/10.5761/atcs.oa.17-00062
dc.description.abstractBackground: The interaction between valvular aortic stenosis (AS) and arterial stiffness, as well as the impact of aortic valve replacement (AVR) on arterial stiffness, remains unclear. In this study, we aimed to evaluate the degree of AS severity on non-invasive pulse wave velocity (PWV) measurements. We also searched whether the AVR procedure favorably affects PWV. Methods: In all, 38 patients undergoing AVR for chronic AS were included. The degree of aortic stiffness was measured with PWV at both baseline and 6 months after AVR. Improvement in aortic stiffness was defined as the absolute decrease in PWV at 6 months compared to the baseline value. Results: The study population had a mean age of 59 ± 16 years, mean aortic gradient of 47.1 ± 6.4 mmHg, and mean aortic valve area (AVA) index of 0.45 ± 0.11 cm²/m². Baseline PWV values correlated positively with the mean aortic gradient (r = 0.350, p = 0.031) and negatively with the AVA index (r = -0.512, p = 0.001). The mean PWV improved in 20 patients (53%) and worsened in 18 patients (47%). The baseline New York Heart Association (NYHA) class (odds ratio [OR] = 1.023, 95% confidence interval [CI] = 1.005–1.041, p = 0.041) and AVA index (OR = 1.040, 96% CI = 1.023–1.057, p = 0.028) emerged as the independent predictors of improvement in PWV following AVR. Conclusion: The severity of AS was significantly associated with baseline PWV. In general, the mean PWV did not change with AVR. Baseline NYHA class and the AVA index independently predicted PWV improvement following AVR. Since the change in PWV after AVR was polarized based on the patients’ characteristics, such as preoperative NYHA functional class or AVA index, further studies are needed to confirm clinical significance of PWV change following AVR in severe AS patients.en_US
dc.language.isoengen_US
dc.publisherJapanese Association for Coronary Artery Surgeryen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAortic Stenosisen_US
dc.subjectAortic Stiffnessen_US
dc.subjectPulse Wave Velocityen_US
dc.titleChanges in aortic pulse wave velocity and the predictors of improvement in arterial stiffness following aortic valve replacementen_US
dc.typearticleen_US
dc.relation.journalAnnals of Thoracic and Cardiovascular Surgeryen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalıen_US
dc.authorid0000-0003-0230-6575en_US
dc.authorid0000-0002-4281-0867en_US
dc.authorid0000-0003-2995-8792en_US
dc.authorid0000-0002-0799-4875en_US
dc.identifier.volume23en_US
dc.identifier.issue5en_US
dc.identifier.startpage248en_US
dc.identifier.endpage255en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.5761/atcs.oa.17-00062en_US


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