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dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorKırmızı, Neriman İpek
dc.contributor.authorCengiz, Nureddin
dc.contributor.authorErdoğan, Ender
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:16Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:16Z
dc.date.issued2016en_US
dc.identifier.citationÖzbek, H., Kırmızı, N. İ., Cengiz, N. ve Erdoğan, E. (2016). Hepatoprotective effects of coriandrum sativum essential oil against acute hepatotoxicity induced by carbon tetrachloride on rats. Acta Pharmaceutica Sciencia, 54(1), 35-40. https://dx.doi.org/10.23893/1307-2080.APS.0543en_US
dc.identifier.issn1307-2080
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1112
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.0543
dc.description.abstractThe aim of this study was to evaluate effect of Coriandrum sativum (CS) essential oil in rat model of carbon tetrachloride (CCl4) induced liver toxicity. Experimental groups were formed as follows: isotonic saline solution (ISS), silibinin, CS-1 (0,3ml/ kg), CS-2 (0,6 ml/kg). Agents were administered intraperitoneally. Blood and liver tissues were collected at the end of the study ended. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured. Liver tissues were evaluated histopathologically. One-way analysis of variance (ANOVA) was used for statistical analyses.As a result silibinin and CS-2 decreased blood AST and ALT levels of their groups and these biochemical results were supported by histopathological results. In conclusion this study has provided evidence that Coriandrum sativum essential oil has significant hepatoprotective effect on carbon tetrachloride induced liver toxicity in rats.en_US
dc.language.isoengen_US
dc.publisherUniversity of Istanbulen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarbon Tetrachlorideen_US
dc.subjectCoriandrum Sativumen_US
dc.subjectEssential Oilen_US
dc.subjectHepatoprotective Activityen_US
dc.subjectRatsen_US
dc.titleHepatoprotective effects of coriandrum sativum essential oil against acute hepatotoxicity induced by carbon tetrachloride on ratsen_US
dc.typearticleen_US
dc.relation.journalActa Pharmaceutica Scienciaen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Eczane Hizmetleri Ana Bilim Dalıen_US
dc.authorid0000-0002-8084-7855en_US
dc.identifier.volume54en_US
dc.identifier.issue1en_US
dc.identifier.startpage35en_US
dc.identifier.endpage40en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.23893/1307-2080.APS.0543en_US


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