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dc.contributor.authorKayağil, İsmail
dc.contributor.authorTay, Naime Funda
dc.contributor.authorKonak, Hüseyin Yaşar
dc.contributor.authorİspir, Cihan
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:15Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:15Z
dc.date.issued2016en_US
dc.identifier.citationKayağil, İ., Tay, N. F., Konak, H. Y., İspir, C. ve Demirayak, Ş. (2016). Synthesis, structure elucidation and determination of acid dissociation constant, tautomerism of pyrido [1,2-a] benzimidazole-2,4-dione. Acta Pharmaceutica Sciencia, 54(1), 23-34. https://dx.doi.org/10.23893/1307-2080.APS.0542en_US
dc.identifier.issn1307-2080
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1110
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.0542
dc.description.abstractThe first starting material, 1H-2-acetylbenzimidazole, 4, was synthesized by o-phenylenediamine, 1, and lactic acid solution, 2, in hydrochloric acid medium on the first step than, oxidation reaction was performed by CrO3 in acetic acid medium on the second step. The last starting material, ethyl 2-(2-acetylbenzimidazol-1-yl) acetate, 6, was synthesized by using first starting material, 4, ethyl 2-bromoacetate, 5, and K2 CO3 in acetone medium. The target compound, pyrido[1,2-a] benzimidazole-2,4-dione, 7, was synthesized by using the last starting material, 5, in sodium ethoxide medium. The compound, 7, can be found in two forms which are keto and enol which would be evaluated in this study. For the evaluation, it was performed some spectroscopic studies. In addition, it was evaluated experimentally obtained acidity constant, pKa value and tautomeric equilibrium of the compound, 7, by using ultraviolet-visible (UV-Vis) spectrophotometer. All of these studies have shown that the valid form of the compound, 7, is keto form.en_US
dc.language.isoengen_US
dc.publisherUniversity of Istanbulen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcidity Constanten_US
dc.subjectPKa Valueen_US
dc.subjectPyrido [1,2-a] Benzimidazoleen_US
dc.subjectTautomerismen_US
dc.titleSynthesis, structure elucidation and determination of acid dissociation constant, tautomerism of pyrido [1,2-a] benzimidazole-2,4-dioneen_US
dc.typearticleen_US
dc.relation.journalActa Pharmaceutica Scienciaen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalıen_US
dc.identifier.volume54en_US
dc.identifier.issue1en_US
dc.identifier.startpage23en_US
dc.identifier.endpage34en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.23893/1307-2080.APS.0542en_US


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