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dc.contributor.authorMutlu, Ayşe Gül
dc.contributor.authorBilginer, Abdulkerim
dc.contributor.authorKayağil, İsmail
dc.contributor.authorYıldız, Hülya
dc.contributor.authorBayhan, Ülkü
dc.contributor.authorYılmaz, İnanç
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:14Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:14Z
dc.date.issued2017en_US
dc.identifier.citationMutlu, A. G., Bilginer, A., Kayağil, İ., Yıldız, H., Bayhan, Ü., Yılmaz, İ. ... Demirayak, Ş. (2017). The effects of some imidazopyrazine derivatives on telomerase inhibition, mtDNA damage and mtDNA copy number. Acta Pharmaceutica Sciencia, 55(3), 31-41. https://dx.doi.org/10.23893/1307-2080.APS.05517en_US
dc.identifier.issn1307-2080
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1101
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.05517
dc.description.abstractImidazopyrazine derivatives have been studied for their curative effects on some diseases like cancer and neurological problems; also, some of these molecules have been patented. Primary human cells exhibit limited replicative potential but the cancer cells divided unlimitedly with passage in culture. This immortality is mainly a result of telomerase activity. We investigated the possible telomerase inhibitor effect and possible mtDNA damage action of five imidazopyrazine derivatives. Telomerase activities were measured by the PCR-ELISA based TRAP method and mtDNA damage assays were achieved by quantitative PCR. We used zebrafish as a model organism for our research. In the application of 6-(4-Metylphenyl-8-(4-chlorophenyl)imidazo[1,2-a]pyrazine (C19H14N3Cl), it was determined that this compound inhibit telomerase activities to a statistically significant degree. The obtained results from molecular docking studies also supported the experimental results. Accordingly, this compound has the probability to be used as an anti-cancer agent after detailed studies.en_US
dc.description.sponsorshipFirat University Scientific Research Projects Management Unit: 0305-NAP-16, 0214-YL-14en_US
dc.language.isoengen_US
dc.publisherUniversity of Istanbulen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnticancer Drugsen_US
dc.subjectImidazopyrazine Derivativesen_US
dc.subjectmtDNA Copy Numberen_US
dc.subjectmtDNA Damageen_US
dc.subjectTelomerase Inhibitionen_US
dc.titleThe effects of some imidazopyrazine derivatives on telomerase inhibition, mtDNA damage and mtDNA copy numberen_US
dc.typearticleen_US
dc.relation.journalActa Pharmaceutica Scienciaen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalıen_US
dc.authorid0000-0002-0841-1299en_US
dc.identifier.volume55en_US
dc.identifier.issue3en_US
dc.identifier.startpage31en_US
dc.identifier.endpage41en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.23893/1307-2080.APS.05517en_US


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