dc.contributor.author | Mutlu, Ayşe Gül | |
dc.contributor.author | Bilginer, Abdulkerim | |
dc.contributor.author | Kayağil, İsmail | |
dc.contributor.author | Yıldız, Hülya | |
dc.contributor.author | Bayhan, Ülkü | |
dc.contributor.author | Yılmaz, İnanç | |
dc.contributor.author | Demirayak, Şeref | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:36:14Z | |
dc.date.available | 10.07.201910:49:14 | |
dc.date.available | 2019-07-10T19:36:14Z | |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | Mutlu, A. G., Bilginer, A., Kayağil, İ., Yıldız, H., Bayhan, Ü., Yılmaz, İ. ... Demirayak, Ş. (2017). The effects of some imidazopyrazine derivatives on telomerase inhibition, mtDNA damage and mtDNA copy number. Acta Pharmaceutica Sciencia, 55(3), 31-41. https://dx.doi.org/10.23893/1307-2080.APS.05517 | en_US |
dc.identifier.issn | 1307-2080 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/1101 | |
dc.identifier.uri | https://dx.doi.org/10.23893/1307-2080.APS.05517 | |
dc.description.abstract | Imidazopyrazine derivatives have been studied for their curative effects on some diseases like cancer and neurological problems; also, some of these molecules have been patented. Primary human cells exhibit limited replicative potential but the cancer cells divided unlimitedly with passage in culture. This immortality is mainly a result of telomerase activity. We investigated the possible telomerase inhibitor effect and possible mtDNA damage action of five imidazopyrazine derivatives. Telomerase activities were measured by the PCR-ELISA based TRAP method and mtDNA damage assays were achieved by quantitative PCR. We used zebrafish as a model organism for our research. In the application of 6-(4-Metylphenyl-8-(4-chlorophenyl)imidazo[1,2-a]pyrazine (C19H14N3Cl), it was determined that this compound inhibit telomerase activities to a statistically significant degree. The obtained results from molecular docking studies also supported the experimental results. Accordingly, this compound has the probability to be used as an anti-cancer agent after detailed studies. | en_US |
dc.description.sponsorship | Firat University Scientific Research Projects Management Unit: 0305-NAP-16, 0214-YL-14 | en_US |
dc.language.iso | eng | en_US |
dc.publisher | University of Istanbul | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Anticancer Drugs | en_US |
dc.subject | Imidazopyrazine Derivatives | en_US |
dc.subject | mtDNA Copy Number | en_US |
dc.subject | mtDNA Damage | en_US |
dc.subject | Telomerase Inhibition | en_US |
dc.title | The effects of some imidazopyrazine derivatives on telomerase inhibition, mtDNA damage and mtDNA copy number | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Acta Pharmaceutica Sciencia | en_US |
dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-0841-1299 | en_US |
dc.identifier.volume | 55 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 31 | en_US |
dc.identifier.endpage | 41 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.23893/1307-2080.APS.05517 | en_US |
dc.identifier.scopusquality | Q4 | en_US |