dc.contributor.author | Berk, Barkın | |
dc.contributor.author | Atlas Tahirovic, Yeşim | |
dc.contributor.author | Bülbül, Emre Fatih | |
dc.contributor.author | Biltekin, Sevde Nur | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:36:13Z | |
dc.date.available | 10.07.201910:49:14 | |
dc.date.available | 2019-07-10T19:36:13Z | |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | Berk, B., Atlas Tahirovic, Y., Bülbül, E. F. ve Biltekin, S. N. (2017). The synthesis, antimicrobial activity studies, and molecular property predictions of novel benzothiazole-2-thione derivatives. Acta Pharmaceutica Sciencia, 55(3), 17-28. https://dx.doi.org/10.23893/1307-2080.APS.05516 | en_US |
dc.identifier.issn | 1307-2080 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/1100 | |
dc.identifier.uri | https://dx.doi.org/10.23893/1307-2080.APS.05516 | |
dc.description.abstract | Benzothiazoles and 2-mercaptobenzothiazoles are important classes of bioactive organic scaffolds possessing antibacterial, antifungal, antitubercular, antiinflamma-tory, antidiabetic, and antimalarial properties. In recent years, prediction of drug-likeness, molecular, absorption, distribution, metabolism, and excretion (ADME) properties using in silico techniques has become a standard procedure for the evaluation of molecules in terms of their potential clinical use. In this study, compounds structured 6-benzoyl-3-substitutedmethylbenzo[d]thiazole-2(3H)-thione were synthesized using the Mannich reaction starting from 2-mercaptobenzothiazole. The antibacterial and antifungal activities of these compounds were determined against Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Candida albicans, Candida krusei, and Candida parapisilosis using a broth microdilution method. An additional analysis was undertaken using the in silico technique to predict the drug-likeness, molecular, and ADME properties of these molecules. Among all the compounds, respectively, Compounds 1-4 and 6-11 exhibited good minimum inhibition concentration values against Staphylococcus aureus and Candida species with promising predicted properties. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | University of Istanbul | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | ADME | en_US |
dc.subject | Antifungal | en_US |
dc.subject | Benzothiazole-2-Thione | en_US |
dc.subject | Candida Albicans | en_US |
dc.subject | In Silico | en_US |
dc.subject | Molecular Properties | en_US |
dc.title | The synthesis, antimicrobial activity studies, and molecular property predictions of novel benzothiazole-2-thione derivatives | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Acta Pharmaceutica Sciencia | en_US |
dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-6047-2796 | en_US |
dc.authorid | 0000-0003-1896-2729 | en_US |
dc.identifier.volume | 55 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 17 | en_US |
dc.identifier.endpage | 28 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.23893/1307-2080.APS.05516 | en_US |
dc.identifier.scopusquality | Q4 | en_US |