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dc.contributor.authorMert Biberoğlu, Fatma
dc.contributor.authorErdem, Nihal Zekiye
dc.contributor.authorÖzdenkaya, Yaşar
dc.contributor.authorÖzdemir, Ekrem Musa
dc.contributor.authorSaka, Burcu
dc.date.accessioned2023-05-31T09:16:53Z
dc.date.available2023-05-31T09:16:53Z
dc.date.issued2023en_US
dc.identifier.citationMert Biberoğlu, F., Erdem, N. Z., Özdenkaya, Y., Özdemir, E. M. ve Saka, B. (2023). Effects of whey Protein, Omega-3 Fatty Acid and Roux-En-Y gastric bypass on body weight, biochemical parameters and organ functions in an obese rat model: Experimental research. Obesity Surgery, 33(5), 1553-1563. https://doi.org/10.1007/s11695-023-06560-zen_US
dc.identifier.issn0960-8923
dc.identifier.issn1708-0428
dc.identifier.urihttps://doi.org/10.1007/s11695-023-06560-z
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11001
dc.description.abstractPurpose: Extreme obesity (EO) is one of the biggest public health problems in the world and has grown considerably over the years. The aim of the study is to examine the effect of Roux-en-Y gastric bypass (RYGB), whey protein (WP), and omega-3 polyunsaturated fatty acid (PUFA) supplementation applied to EO rats on weight loss, histopathological changes in internal organs and biochemical alterations. Materials and Methods: Wistar albino female rats (n = 28) were used in the study and randomly divided into four groups. All rats were made obese by adding high fructose corn syrup (HFCS) to their drinking water. After the EO, WP and omega-3 PUFA supplementation was given and RYGB process was applied. At the end of the study, glucose, total cholesterol, HDL, VLDL, AST, ALT and uric acid changes and liver, kidney and pancreatic tissues were evaluated histopathologically. Results: WP and omega-3 PUFA supplementation decreased body weight (p > 0.05). Omega-3 PUFA and RYGB caused a decrease in total cholesterol (p < 0.05), WP decreased HDL (p < 0.05), WP and omega-3 PUFA caused an increase in ALT (p < 0.05). WP has been shown to have greater curative effects in rat liver and kidney tissues. It has been determined that RYGB causes necrosis in the liver and HFCS causes inflammation in the kidney. Conclusion: In the study; the positive effects of WP, omega-3 PUFA and bariatric surgery on obesity and dyslipidemia have been demonstrated. With this result, it was determined that WP, omega-3 PUFA supplementation and bariatric surgery were not superior to each other. Graphical abstract: [Figure not available: see fulltext.]en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExtreme Obesityen_US
dc.subjectOmega-3 PUFAen_US
dc.subjectRoux-En-Y Gastric Bypassen_US
dc.subjectWhey Proteinen_US
dc.titleEffects of whey Protein, Omega-3 Fatty Acid and Roux-En-Y gastric bypass on body weight, biochemical parameters and organ functions in an obese rat model: Experimental researchen_US
dc.typearticleen_US
dc.relation.ispartofObesity Surgeryen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Beslenme ve Diyetetik Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsüen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Tıbbi Araştırma Merkezi (MEDİTAM)en_US
dc.authorid0000-0002-5625-3387en_US
dc.authorid0000-0001-7046-9515en_US
dc.authorid0000-0003-0428-2511en_US
dc.authorid0000-0001-9416-7757en_US
dc.identifier.volume33en_US
dc.identifier.issue5en_US
dc.identifier.startpage1553en_US
dc.identifier.endpage1563en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s11695-023-06560-zen_US
dc.institutionauthorMert Biberoğlu, Fatma
dc.institutionauthorErdem, Nihal Zekiye
dc.institutionauthorÖzdenkaya, Yaşar
dc.institutionauthorÖzdemir, Ekrem Musa
dc.identifier.wosqualityQ2en_US
dc.identifier.wos000960207000001en_US
dc.identifier.scopus2-s2.0-85150949050en_US
dc.identifier.pmid36971930en_US
dc.identifier.scopusqualityQ1en_US


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