dc.contributor.author | Özbek, Hanefi | |
dc.contributor.author | Yılmaz, Betül Sever | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:36:13Z | |
dc.date.available | 10.07.201910:49:14 | |
dc.date.available | 2019-07-10T19:36:13Z | |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | Özbek, H. ve Yılmaz, B. S. (2017). Anti-inflammatory and hypoglycemic activities of alpha-pinene. Acta Pharmaceutica Sciencia, 55(4), 7-14. https://dx.doi.org/10.23893/1307-2080.APS.05522 | en_US |
dc.identifier.issn | 1307-2080 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/1098 | |
dc.identifier.uri | https://dx.doi.org/10.23893/1307-2080.APS.05522 | |
dc.description.abstract | The aim of this study is to investigate the anti-inflammatory and hypoglycemic activities of alpha-pinene, and to find the median lethal dose (LD50) level in mice. Lethal dose levels of alpha-pinene were investigated using a probit analysis method. For the anti-inflammatory activity measurement seven different groups were established and alpha-pinene was administered in four different doses: 0.05, 0.10, 0.25 and 0.50 mL/kg. For the evaluation of hypoglycemic activity six different groups, consisting of diabetic and healthy mice, were established. The strongest anti-inflammatory activity of alpha-pinene was observed with a 0.50 mL/kg dosage. The median effective dose (ED50) value of alpha-pinene was found to be 0.039 mL/kg. In diabetic mice ?-pinene showed significant levels of hypoglycemic activity at the 2nd and 24th hours. LD50 level of ?-pinene was determined to be 2.076 mL/kg. As a result, we conclude that alpha-pinene is a molecule that displays hypoglycemic and anti-inflammatory activities. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | University of Istanbul | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Alpha-Pinene | en_US |
dc.subject | Anti-Inflammatory Activity | en_US |
dc.subject | Hypoglycemic Activity | en_US |
dc.subject | Mice | en_US |
dc.subject | Rats | en_US |
dc.title | Anti-inflammatory and hypoglycemic activities of alpha-pinene | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Acta Pharmaceutica Sciencia | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-8084-7855 | en_US |
dc.identifier.volume | 55 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 7 | en_US |
dc.identifier.endpage | 14 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.23893/1307-2080.APS.05522 | en_US |
dc.identifier.scopusquality | Q4 | en_US |