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dc.contributor.authorUlaş, Mustafa
dc.contributor.authorAkbaş, E.
dc.contributor.authorAkbaş, S.
dc.contributor.authorAktemur, Gizem
dc.contributor.authorDurcanoğlu, N.
dc.contributor.authorAksak, K.
dc.contributor.authorAtalar, Aslan Arda
dc.contributor.authorYıldırım, S.
dc.contributor.authorAkalın, I.
dc.date.accessioned2023-05-23T07:51:38Z
dc.date.available2023-05-23T07:51:38Z
dc.date.issued2023en_US
dc.identifier.citationUlaş, M., Akbaş, E., Akbaş, S., Aktemur, G., Durcanoğlu, N., Aksak, K. ... Akalın, I. (2023). Physiological aspect of apoptosis-regulating microRNAs expressions during fasting. European Review for Medical and Pharmacological Sciences, 27(6), 2210-2215. https://doi.org/10.26355/eurrev_202303_31754en_US
dc.identifier.issn1128-3602
dc.identifier.urihttps://doi.org/10.26355/eurrev_202303_31754
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10952
dc.description.abstractOBJECTIVE: Fasting is an activi-ty that requires a certain calorie restriction with-out consuming food or drinks for a certain pe-riod of daytime. However, fasting triggers ma-ny complex events, including activating cellular stress response pathways, autophagy promo-tion, apoptosis pathways, and a change in hor-monal balance. Among the many events affect-ing the regulation of apoptosis, the expression of microRNAs (miRNAs) plays an important role. Therefore, we aimed to investigate the levels and importance of miRNA expression in fasting.PATIENTS AND METHODS: The expressions of 19 miRNAs regulating different pathways from saliva samples, isolated by matching healthy university students (n = 34) as group 1 (fasting for 17 consecutive hours) and group 2 (testing 70 minutes after meal consumption), were exam-ined using the real-time PCR method. RESULTS: In fasting, modulation of apoptotic pathways by miRNAs triggers anti-pathogenic ef-fects, and the adaptation of abnormal cells in the body decreases. For this reason, vital diseases, such as cancer, can be treated by preventing the proliferation and growth of cancerous cells by in-creasing programmed cell death due to the down -regulation expression mechanism of miRNAs.CONCLUSIONS: Our study aims to improve the knowledge about the mechanisms and func-tions of miRNAs in various apoptosis pathways during fasting and may be a model for further fu-ture physiological and pathological studies.en_US
dc.language.isoengen_US
dc.publisherVerduci Publisheren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectMicroRNAsen_US
dc.subjectFastingen_US
dc.subjectPolymerase Chain Reactionen_US
dc.subjectApoptotic Pathwaysen_US
dc.subjectMiR/221-222en_US
dc.titlePhysiological aspect of apoptosis-regulating microRNAs expressions during fastingen_US
dc.typearticleen_US
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciencesen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Geleneksel ve Tamamlayıcı Tıp Ana Bilim Dalıen_US
dc.identifier.volume27en_US
dc.identifier.issue6en_US
dc.identifier.startpage2210en_US
dc.identifier.endpage2215en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.26355/eurrev_202303_31754en_US
dc.institutionauthorAkbaş, E.
dc.institutionauthorAkbaş, S.
dc.identifier.wosqualityQ2en_US
dc.identifier.wos000971936600004en_US
dc.identifier.scopus2-s2.0-85151749201en_US
dc.identifier.pmid37013738en_US
dc.identifier.scopusqualityQ2en_US


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