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dc.contributor.authorEmekli, Nesrin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:12Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:12Z
dc.date.issued2017en_US
dc.identifier.citationEmekli, N. (2017). Can tissue factor, a multifactorial molecule of the hemostasis, be used as a biomarker for thrombosis, inflammation and cancer? Acta Pharmaceutica Sciencia, 55(3), 93-104. https://dx.doi.org/10.23893/1307-2080.APS.05521en_US
dc.identifier.issn1307-2080
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1094
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.05521
dc.description.abstractTissue factor (TF) is a transmembrane protein found in many tissues and is active in various biological reactions. It is a member of the cytokine receptor superfam-ily and is referred to as CD 142 because of this feature. TF is also known as Factor III in the coagulation system and binds FVII/VIIa. The TF and FVIIa complex has both procoagulant and signaling activities. It functions in many biological processes, including hemostasis, thrombosis, inflammation and cancer. TF is essential for haemostasis but increased TF expression within atherosclerotic plaques and TF positive microparticles were detected in thrombotic conditions. TF increases inflammation by enhancing intravascular fibrin deposition and activates protease-activated receptors (PARs). TF and FVIIa complex also contribute to tumor growth by activating PAR2. Recent retrospective studies have shown that TF positive microparticles increase in the plasma of cancer patients. Therefore TF may be suggested to be used as a biomarker. However further studies are required to reveal the availability of TF as a biomarker to identify cancer and risk of thromosis and inflammation.en_US
dc.language.isoengen_US
dc.publisherUniversity of Istanbulen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCanceren_US
dc.subjectHemostasisen_US
dc.subjectInflammationen_US
dc.subjectThrombosisen_US
dc.subjectTissue Factoren_US
dc.titleCan tissue factor, a multifactorial molecule of the hemostasis, be used as a biomarker for thrombosis, inflammation and cancer?en_US
dc.typearticleen_US
dc.relation.journalActa Pharmaceutica Scienciaen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.identifier.volume55en_US
dc.identifier.issue3en_US
dc.identifier.startpage93en_US
dc.identifier.endpage104en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.23893/1307-2080.APS.05521en_US


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