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dc.contributor.authorBüyükuslu, Nihal
dc.contributor.authorÖztürk, Rabia İclal
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:11Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:11Z
dc.date.issued2018en_US
dc.identifier.citationBüyükuslu, N. ve Öztürk, R. İ. (2018). Polyamine metabolism and obesity: Polyamine metabolic enzymes involved in obesity. Acta Pharmaceutica Sciencia, 56(2), 85-91. https://dx.doi.org/10.23893/1307-2080.APS.05613en_US
dc.identifier.issn1307-2080
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1086
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.05613
dc.description.abstractThe natural polyamines, putrescine, spermidine and spermine are distributed widely in all cells including adipocytes. They are involved in several physiological processes involving gene expression and cell proliferation. The body pool of polyamines is maintained by endogenous biosynthesis, intestinal microorganisms and the diet. A correlation between fat metabolism and polyamine metabolism has been reported in several studies. It was shown that the inhibition of polyamine metabolism enzymes had been associated with increased adipose tissue and weight gain in human and animal models. Ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC) are anabolic enzymes; and spermidine/ spermine N1-acetyltransferase (SSAT) and polyamine oxidase (PAO) are catabolic enzymes which regulate polyamine homoeostasis. Genetically altered polyamine metabolic enzymes resulted in higher tissue adipose content and weight gain indicating potential links between obesity and polyamine metabolism. This review aims to provide details on previously reported sources of data published on polyamine metabolism and obesity.en_US
dc.language.isoengen_US
dc.publisherİstanbul Medipol Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPolyamineen_US
dc.subjectObesityen_US
dc.subjectOrnithine Decarboxylaseen_US
dc.subjectS-Adenosylmethionine Decarboxylaseen_US
dc.subjectSpermidine/Spermine N1-Acetyltransferaseen_US
dc.subjectPolyamine Oxidaseen_US
dc.titlePolyamine metabolism and obesity: Polyamine metabolic enzymes involved in obesityen_US
dc.typearticleen_US
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.identifier.volume56en_US
dc.identifier.issue2en_US
dc.identifier.startpage85en_US
dc.identifier.endpage91en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.23893/1307-2080.APS.05613en_US
dc.identifier.scopusqualityQ4en_US


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