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dc.contributor.authorGiray, Betül
dc.contributor.authorYurttaş, Leyla
dc.contributor.authorŞahin, Zafer
dc.contributor.authorBerk, Barkın
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:10Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:10Z
dc.date.issued2019en_US
dc.identifier.citationGiray, B., Yurttaş, L., Şahin, Z., Berk, B. ve Demirayak, Ş. (2019). Antimicrobial evaluation of trisubstituted 2-piperazinyl thiazoles. Acta Pharmaceutica Sciencia, 57(1), 103-108. https://dx.doi.org/10.23893/1307-2080.APS.05707en_US
dc.identifier.issn1307-2080
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1084
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.05707
dc.description.abstractThiazole and basic nitrogen containing rings are important chemical moieties of antimicrobial drugs. In recent, third generation cephalosporins include thiazole ring system. In this study, we synthesized 33 piperazine thiazole derivatives which were thought to show antimicrobial activity. Synthesize were realized with good yield using the method which reports the anticholinesterase properties of these compounds. Similar compounds with the same scaffold (2, 4, 5 trisubstituted thiazoles) are investigated for antimicrobial activity. Compounds 23-27 exhibited MIC: 256 µM against S. aureus ATCC 25923. Besides, 27-33 group showed MIC: 256 µM against K. pneumoniae UC57 and B. cereus. It is remarkable that the compound 27 showed antimicrobial activity against 4 different microorganisms and 26 showed antimicrobial activity against L. monocytogenes by MIC: 32 µM which is same as the standart chloramphenicol.en_US
dc.language.isoengen_US
dc.publisherİstanbul Medipol Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntimicrobialen_US
dc.subjectN-Benzoylthioamideen_US
dc.subjectPiperazineen_US
dc.subjectThiazoleen_US
dc.subjectTrisubstituted Thiazoleen_US
dc.titleAntimicrobial evaluation of trisubstituted 2-piperazinyl thiazolesen_US
dc.typearticleen_US
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalıen_US
dc.authorid0000-0003-1318-6476en_US
dc.authorid0000-0002-5976-676Xen_US
dc.authorid0000-0001-6047-2796en_US
dc.authorid0000-0002-0841-1299en_US
dc.identifier.volume57en_US
dc.identifier.issue1en_US
dc.identifier.startpage103en_US
dc.identifier.endpage108en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.23893/1307-2080.APS.05707en_US
dc.identifier.scopusqualityQ3en_US


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