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dc.contributor.authorBabiloni, Claudio
dc.contributor.authorNoce, Giuseppe
dc.contributor.authorFerri, Raffaele
dc.contributor.authorLizio, Roberta
dc.contributor.authorLopez, Susanna
dc.contributor.authorLorenzo, Ivan
dc.contributor.authorTucci, Federico
dc.contributor.authorSoricelli, Andrea
dc.contributor.authorZurrón, Montserrat
dc.contributor.authorDíaz, Fernando
dc.contributor.authorNobili, Flavio
dc.contributor.authorArnaldi, Dario
dc.contributor.authorFamà, Francesco
dc.contributor.authorButtinelli, Carla
dc.contributor.authorGiubilei, Franco
dc.contributor.authorCipollini, Virginia
dc.contributor.authorMarizzoni, Moira
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorYıldırım, Ebru
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorYener, Görsev
dc.contributor.authorHünerli Gündüz, Duygu
dc.contributor.authorOnorati, Paolo
dc.contributor.authorStocchi, Fabrizio
dc.contributor.authorVacca, Laura
dc.contributor.authorMaestú, Fernando
dc.contributor.authorFrisoni, Giovanni B.
dc.contributor.authordel Percio, Claudio
dc.date.accessioned2023-01-11T09:13:53Z
dc.date.available2023-01-11T09:13:53Z
dc.date.issued2022en_US
dc.identifier.citationBabiloni, C., Noce, G., Ferri, R., Lizio, R., Lopez, S., Lorenzo, I. ... del Percio, C. (2022). Resting state alpha electroencephalographic rhythms are affected by sex in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment: A retrospective and exploratory study. Cerebral Cortex, 32(10), 2197-2215. https://dx.doi.org/10.1093/cercor/bhab348en_US
dc.identifier.issn1047-3211
dc.identifier.issn1460-2199
dc.identifier.urihttps://dx.doi.org/10.1093/cercor/bhab348
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10284
dc.description.abstractIn the present retrospective and exploratory study, we tested the hypothesis that sex may affect cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in normal elderly (Nold) seniors and patients with Alzheimer's disease and mild cognitive impairment (ADMCI). Datasets in 69 ADMCI and 57 Nold individuals were taken from an international archive. The rsEEG rhythms were investigated at individual delta, theta, and alpha frequency bands and fixed beta (14-30 Hz) and gamma (30-40 Hz) bands. Each group was stratified into matched females and males. The sex factor affected the magnitude of rsEEG source activities in the Nold seniors. Compared with the males, the females were characterized by greater alpha source activities in all cortical regions. Similarly, the parietal, temporal, and occipital alpha source activities were greater in the ADMCI-females than the males. Notably, the present sex effects did not depend on core genetic (APOE4), neuropathological (A beta 42/phospho-tau ratio in the cerebrospinal fluid), structural neurodegenerative and cerebrovascular (MRI) variables characterizing sporadic AD-related processes in ADMCI seniors. These results suggest the sex factor may significantly affect neurophysiological brain neural oscillatory synchronization mechanisms underpinning the generation of dominant rsEEG alpha rhythms to regulate cortical arousal during quiet vigilance.en_US
dc.description.sponsorshipMinistry of Health, Italyen_US
dc.language.isoengen_US
dc.publisherOxford University Press Incen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExact Low-Resolution Brain Electromagnetic Source Tomography (eLORETA)en_US
dc.subjectMild Cognitive Impairment due to Alzheimer’s Disease (ADMCI)en_US
dc.subjectResting State Electroencephalographic (rsEEG) Rhythmsen_US
dc.subjectSexen_US
dc.titleResting state alpha electroencephalographic rhythms are affected by sex in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment: A retrospective and exploratory studyen_US
dc.typearticleen_US
dc.relation.ispartofCerebral Cortexen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.departmentİstanbul Medipol Üniversitesi, İMÜ Meslek Yüksekokulu, Elektronörofizyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.authorid0000-0002-0860-0524en_US
dc.authorid0000-0002-7715-3035en_US
dc.authorid0000-0003-4292-5717en_US
dc.identifier.volume32en_US
dc.identifier.issue10en_US
dc.identifier.startpage2197en_US
dc.identifier.endpage2215en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1093/cercor/bhab348en_US
dc.institutionauthorGüntekin, Bahar
dc.institutionauthorYıldırım, Ebru
dc.institutionauthorHanoğlu, Lütfü
dc.identifier.wosqualityQ2en_US
dc.identifier.wos000789377200001en_US
dc.identifier.scopus2-s2.0-85128377064en_US
dc.identifier.pmid34613369en_US
dc.identifier.scopusqualityQ1en_US


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