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dc.contributor.authorGöktürk, Nurcan
dc.contributor.authorŞahin, Hicret
dc.contributor.authorBayramoğlu, Feyza
dc.contributor.authorÇakıcı, Çağrı
dc.contributor.authorBüyükuslu, Nihal
dc.contributor.authorYiğit, Pakize
dc.contributor.authorYiğitbaşı, Türkan
dc.date.accessioned2022-12-21T13:26:20Z
dc.date.available2022-12-21T13:26:20Z
dc.date.issued2022en_US
dc.identifier.citationGöktürk, N., Şahin, H., Bayramoğlu, F., Çakıcı, Ç., Büyükuslu, N., Yiğit, P. ... Yiğitbaşı, T. (2022). Could the increase in oxidative stress be the reason for the increased polyamine levels in diabetic obese and non-diabetic obese patients? Acta Pharmaceutica Sciencia, 60(3), 301-312. https://doi.org/10.23893/1307-2080.APS.6020en_US
dc.identifier.issn1307-2080
dc.identifier.urihttps://doi.org/10.23893/1307-2080.APS.6020
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10160
dc.description.abstractPutresin, spermine, and spermidine are important polyamines found in all living organisms. In this study, as a first in the literature, we aimed to investigate polyamines levels and their relationship with oxidative stress in obese adults. The study was carried out with 85 obese patients and 29 healthy controls. Glucose, HbA1c, urea, uric acid, CRP, Total antioxidant status and Total oxidant status putrescine, spermine and spermidine levels were analysed. The study found putrescine and spermidine levels in obesity (0.25 ±0.13) (2.29 ±0.79) were found to be significantly lower, respectively, than the control group (0.38± 0.08) (1.80 ± 0.68) (p<0.05). It was observed that both OSI and TOS values in the diabetic obese group were statistically higher than both the control group and the non-diabetic obese group. As a result; although polyamine levels are low in obesity, increased oxidative stress in the diabetic obese group caused an increase in polyamine levels.en_US
dc.language.isoengen_US
dc.publisherİstanbul Medipol Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPolyaminesen_US
dc.subjectObesityen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectOxidative Stressen_US
dc.titleCould the increase in oxidative stress be the reason for the increased polyamine levels in diabetic obese and non-diabetic obese patients?en_US
dc.typearticleen_US
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.authorid0000-0002-5213-6933en_US
dc.authorid0000-0002-1757-9843en_US
dc.authorid0000-0002-0757-9743en_US
dc.authorid0000-0002-8662-5284en_US
dc.authorid0000-0003-1420-0989en_US
dc.authorid0000-0002-5919-1986en_US
dc.authorid0000-0002-0675-1839en_US
dc.identifier.volume60en_US
dc.identifier.issue3en_US
dc.identifier.startpage301en_US
dc.identifier.endpage312en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.23893/1307-2080.APS.6020en_US
dc.institutionauthorGöktürk, Nurcan
dc.institutionauthorŞahin, Hicret
dc.institutionauthorBayramoğlu, Feyza
dc.institutionauthorÇakıcı, Çağrı
dc.institutionauthorBüyükuslu, Nihal
dc.institutionauthorYiğit, Pakize
dc.institutionauthorYiğitbaşı, Türkan
dc.identifier.scopus2-s2.0-85137365650en_US
dc.identifier.scopusqualityQ3en_US


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