PubMed İndeksli Yayınlar KoleksiyonuPubMed Indexed Publications Collectionhttps://hdl.handle.net/20.500.12511/49272024-03-29T13:32:56Z2024-03-29T13:32:56ZEarly atherosclerosis and conduction defect in a rare case of dunnigan type familial partial lipodystrophyOlgun, Fatih ErkamGüler, EkremÇeleğen, Muhammed FurkanDemirçelik, BoraKılıçaslan, FethiBoztosun, Bilalhttps://hdl.handle.net/20.500.12511/124022024-03-28T08:48:43Z2024-01-01T00:00:00ZEarly atherosclerosis and conduction defect in a rare case of dunnigan type familial partial lipodystrophy
Olgun, Fatih Erkam; Güler, Ekrem; Çeleğen, Muhammed Furkan; Demirçelik, Bora; Kılıçaslan, Fethi; Boztosun, Bilal
A 45-year-old female patient was admitted to the emergency department with syncope. Her medical history revealed a diagnosis of Familial Partial Lipodystrophy 2 (FPLD2). The patient's electrocardiogram showed a complete atrioventricular (A-V) block, and she had a history of insulin-dependent diabetes mellitus and coronary artery bypass surgery. A severe stenosis was observed in the aortic right coronary artery saphenous vein graft during coronary angiography, which was successfully revascularized. Subsequently, due to persistant syncope attacks, a permanent pacemaker was implanted after an electrophysiological study. This case highlights that serious cardiac conduction defects in patients with FPLD2 may not only be related to coronary artery disease but can also present as direct conduction defects.; Senkop şikayeti ile acil servise başvuran 45 yaşında kadın hastanın öyküsünden ailesel parsiyel lipodistrofi 2 (FPLD2) tanısı aldığı öğrenildi. İnsüline bağımlı diabetes mellitus ve koroner by-pass cerrahisi öyküsü olan hastanın elektrokardiyografisinde A-V tam blok izlendi. Koroner anjiyografide aort-sağ koroner arter safen ven greftinde ciddi darlık görülmesi nedeniyle başarılı revaskülarizasyon uygulandı. Sonrasında, senkop atakları devam eden hastaya yapılan elektrofizyolojik çalışma sonucunda kalıcı kalp pili takıldı. Bu olguda, FPLD2 tanısı olan hastalarda ciddi kardiyak iletim kusurlarının sadece koroner arter hastalığı ile ilişkili olmadığını, hastalığın doğrudan iletim kusurları ile de ortaya çıkabileceğini vurgulamak istedik.
2024-01-01T00:00:00ZEvaluating the effect of daytime sleepiness and sleep quality on balance, fatigue and life quality of shift workersDoǧan, SemanurAras Bayram, Gülayhttps://hdl.handle.net/20.500.12511/124002024-03-28T07:00:41Z2024-01-01T00:00:00ZEvaluating the effect of daytime sleepiness and sleep quality on balance, fatigue and life quality of shift workers
Doǧan, Semanur; Aras Bayram, Gülay
BACKGROUND: Changes in the sleep-wake cycle in shift workers can cause many health problems. OBJECTIVE: The aim of this study was to investigate the relationship between daytime sleepiness and sleep quality on balance, physical activity level, fatigue and quality of life in shift and non-shift workers. METHOD: A total of 58 employees, 29 shifts and 29 non-shifts, were included in the study. Data were collected using the Epworth Sleepiness Scale, the Pittsburgh Sleep Quality Index, the Tandem Posture Test, the One-Foot Stand Test, the Ten-Step Tandem Walking Test, the International Physical Activity Questionnaire-Short Form, the Fatigue Severity Scale, and the Nottingham Health Profile. RESULTS: Individuals working in shifts had higher fatigue severity and daytime sleepiness levels (p < 0.05), while physical activity levels and sleep quality were lower than those working without shifts (p < 0.05). It was determined that as the daytime sleepiness of individuals working in shifts and non-shifts increased, their quality of life decreased (p < 0.05). CONCLUSION: According to the data obtained from the study, individuals working in shifts compared to individuals working without shifts experienced higher levels of daytime sleepiness and fatigue severity level while sleep quality and physical activity level were lower.
2024-01-01T00:00:00ZTreatment outcomes and prognostic factors in patients with driver mutant non-small cell lung cancer and de novo brain metastasesKahraman, SedaKarakaya, SerdarKaplan, Muhammed AliSezgin Göksu, SemaÖztürk, AkınSucuoğlu İşleyen, ZehraHamdard, JamshidYıldırım, SedatŞendur, Mehmet Ali Nahithttps://hdl.handle.net/20.500.12511/123952024-03-26T07:08:51Z2024-01-01T00:00:00ZTreatment outcomes and prognostic factors in patients with driver mutant non-small cell lung cancer and de novo brain metastases
Kahraman, Seda; Karakaya, Serdar; Kaplan, Muhammed Ali; Sezgin Göksu, Sema; Öztürk, Akın; Sucuoğlu İşleyen, Zehra; Hamdard, Jamshid; Yıldırım, Sedat; Şendur, Mehmet Ali Nahit
Central nervous system (CNS) metastases can be seen at a rate of 30% in advanced stages for patients with non-small cell lung cancer (NSCLC). Growing evidence indicates the predictive roles of driver gene mutations in the development of brain metastases (BM) in recent years, meaning that oncogene-driven NSCLC have a high incidence of BM at diagnosis. Today, 3rd generation targeted drugs with high intracranial efficacy, which can cross the blood–brain barrier, have made a positive contribution to survival for these patients with an increased propensity to BM. It is important to update the clinical and pathological factors reflected in the survival with real-life data. A multi-center, retrospective database of 306 patients diagnosed with driver mutant NSCLC and initially presented with BM between between November 2008 and September 2022 were analyzed. The median progression-free survival (mPFS) was 12.25 months (95% CI, 10–14.5). While 254 of the patients received tyrosine kinase inhibitor (TKI), 51 patients received chemotherapy as first line treatment. The median intracranial PFS (iPFS) was 18.5 months (95% CI, 14.8–22.2). The median overall survival (OS) was 29 months (95% CI, 25.2–33.0). It was found that having 3 or less BM and absence of extracranial metastases were significantly associated with better mOS and iPFS. The relationship between the size of BM and survival was found to be non-significant. Among patients with advanced NSCLC with de novo BM carrying a driver mutation, long-term progression-free and overall survival can be achieved with the advent of targeted agents with high CNS efficacy with more conservative and localized radiotherapy modalities.
2024-01-01T00:00:00ZDental students' and dental school graduates' practical skills: An international survey of perceptions of national dental associations in europeWolf, Thomas GerhardDianiskova, SimoneCavalle, EdoardoAliyeva, RenaCagetti, Maria-GraziaCampus, GuglielmoDeschner, JamesForna, Norinaİlhan, DuyguSaag, Marehttps://hdl.handle.net/20.500.12511/123942024-03-29T06:24:32Z2024-01-01T00:00:00ZDental students' and dental school graduates' practical skills: An international survey of perceptions of national dental associations in europe
Wolf, Thomas Gerhard; Dianiskova, Simone; Cavalle, Edoardo; Aliyeva, Rena; Cagetti, Maria-Grazia; Campus, Guglielmo; Deschner, James; Forna, Norina; İlhan, Duygu; Saag, Mare
Purpose: Dental students learn knowledge and practical skills to provide oral health care to the population. Practical skills must be maintained or continuously developed throughout a professional career. This cross-sectional survey aimed to evaluate the perception of practical skills of dental students and dental-school graduates by national dental associations (NDAs) in Materials and Methods: A questionnaire of 14 items collected information on pre-/postgraduate areas. Results: A total of 25 countries participated (response rate: 69.4%), with 80.0% having minimum requirements for practical skills acquisition and 64.0% starting practical training in the 3rd year of study. In countries where clinical practical work on patients begins in the 2nd year of study, practical skills of graduates are perceived as average, starting in the 3rd year of study as mainly good, starting in the 4th as varying widely from poor to very good. In total, 76.0% of respondents feel that improvements are needed before entering dental practice. Improvements could be reached by treating more patients in dental school (32.0%), increasing the quantity of clinical training (20.0%), or having more clinical instructors (12.0%). In 56.0% of the countries, it is possible to open one's own dental practice immediately after graduation, and in 16.0%, prior vocational training is mandatory. Conclusions: All participating countries in the ERO-FDI zone reported practical training in dental school, most starting in the 3rd year of study. The perception of practical skills of dental students and dental-school graduates among NDAs is very heterogeneous. Reasons for the perceived deficiencies should be further explored.
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