Makale KoleksiyonuArticle Collectionhttps://hdl.handle.net/20.500.12511/41782024-03-29T08:39:17Z2024-03-29T08:39:17ZSleep quality, quality of life, fatigue, and mental health in COVID-19 post-pandemic Türkiye: a cross-sectional studyBener, AbdulbariMorgül, EbruTokaç, MahmutVentriglio, Antoniohttps://hdl.handle.net/20.500.12511/123802024-03-20T10:06:40Z2024-01-01T00:00:00ZSleep quality, quality of life, fatigue, and mental health in COVID-19 post-pandemic Türkiye: a cross-sectional study
Bener, Abdulbari; Morgül, Ebru; Tokaç, Mahmut; Ventriglio, Antonio
Aim: This study explores the predictors and associated risk factors of sleep quality, quality of life, fatigue, and mental health among the Turkish population during the COVID-19 post-pandemic period. Materials and methods: A cross-sectional survey using multi-stage, stratified random sampling was employed. In total, 3,200 persons were approached. Of these, 2,624 (82%) completed the questionnaire package consisting of socio-demographic information, Pittsburgh Sleep Quality Index (PSQI), the WHO Quality of Life Brief Version (WHOQOL-BREF), Fatigue Assessment Scale (FAS), Patients Health Questionnaire (PHQ-15), GAD-7 anxiety scale, and the 21-item Depression, Anxiety, Stress Scale (DASS-21). Results: Significant differences between genders were found regarding socio-demographic characteristics (p < 0.01). Using PHQ-15 for depressive disorders, significant differences were found between normal and high severity scores (≥ 10), regarding age group (p < 0.001), gender (p = 0.049), educational level (p < 0.001), occupational status (p = 0.019), cigarette smoking (p = 0.002), waterpipe-narghile smoking (p = 0.039), and co-morbidity (p = 0.003). The WHOQOL-BREF indicated strong correlations between public health, physical health, psychological status, social relationships, environmental conditions, and sleep disorders (p < 0.01). Furthermore, comparisons of the prevalence of mental health symptoms and sleeping with PHQ-15 scores ≥ 10 (p = 0.039), fatigue (p = 0.012), depression (p = 0.009), anxiety (p = 0.032), stress (p = 0.045), and GAD-7 (p < 0.001), were significantly higher among the mental health condition according to sleeping disorder status. Multiple regression analysis revealed that DASS21 stress (p < 0.001), DASS21 depression (p < 0.001), DASS21 anxiety (p = 0.002), physical health (WHOQOL-BREF) (p = 0.007), patient health depression-PHQ-15 (p = 0.011), psychological health (WHOQOL-BREF) (p = 0.012), fatigue (p = 0.017), and environmental factors (WHOQOL-BREF) (p = 0.041) were the main predictor risk factors associated with sleep when adjusted for gender and age. Conclusion: The current study has shown that sleep quality was associated with the mental health symptoms of depression, anxiety, stress, and fatigue. In addition, insufficient sleep duration and unsatisfactory sleep quality seemed to affect physical and mental health functioning.
2024-01-01T00:00:00ZDefining minimal invasive surgical therapy for benign prostatic obstruction surgery: Perspectives from a global knowledge, attitude, and practice surveyCheng, Bryan Kwun-ChungYuen, Steffi Kar-KeiCastellani, DanieleWroclawski, Marcelo LangerZhao, HongdaChiruvella, MallikarjunaChua, Wei -JinTiong, Ho-YeeTanıdır, Yılörende la Rosette, Jean J. M. C. H.Gauhar, Vineethttps://hdl.handle.net/20.500.12511/123742024-03-19T08:31:56Z2024-01-01T00:00:00ZDefining minimal invasive surgical therapy for benign prostatic obstruction surgery: Perspectives from a global knowledge, attitude, and practice survey
Cheng, Bryan Kwun-Chung; Yuen, Steffi Kar-Kei; Castellani, Daniele; Wroclawski, Marcelo Langer; Zhao, Hongda; Chiruvella, Mallikarjuna; Chua, Wei -Jin; Tiong, Ho-Yee; Tanıdır, Yılören; de la Rosette, Jean J. M. C. H.; Gauhar, Vineet
Objective: To scrutinize the definitions of minimal invasive surgical therapy (MIST) and to investigate urologists' knowledge, attitudes, and practices for benign prostatic obstruction surgeries. Methods: A 36 -item survey was developed with a Delphi method. Questions on definitions of MIST and attitudes and practices of benign prostatic obstruction surgeries were included. Urologists were invited globally to complete the online survey. Consensus was achieved when more than or equal to 70% responses were "agree or strongly agree" and less than or equal to 15% responses were "disagree or strongly disagree" (consensus agree), or when more than or equal to 70% responses were "disagree or strongly disagree" and less than or equal to 15% responses were "agree or strongly agree" (consensus disagree). Results: The top three qualities for defining MIST were minimal blood loss (n=466, 80.3%), fast post -operative recovery (n=4 31, 74 .3%), and short hospital stay (n=425, 73.3%). The top three surgeries that were regarded as MIST were Urolift (R) (n=361, 62.2%), Rezum (R) (n=351, 60.5%), and endoscopic enucleation of the prostate (EEP) (n=332, 57.2%). Consensus in the knowledge section was achieved for the superiority of Urolift (R), Rezum (R), and iTIND (R) over transurethral resection of the prostate with regard to blood loss, recovery, day surgery feasibility, and post -operative continence. Consensus in the attitudes section was achieved for the superiority of Urolift (R), Rezum (R), and iTIND (R) over transurethral resection of the prostate with regard to blood loss, recovery, and day surgery feasibility. Consensus on both sections was achieved for EEP as the option with the better symptoms and flow improvement, lower retreatment rate, and better suitable for prostate more than 80 mL. Conclusion: Minimal blood loss, fast post -operative recovery, and short hospital stay were the most important qualities for defining MIST. Urolift (R), Rezum (R), and EEP were regarded as MIST by most urologists.
2024-01-01T00:00:00ZIndividual ingredients of NP-101 (Thymoquinone formula) inhibit SARS-CoV-2 pseudovirus infectionMaen, AbdelrahimGök Yavuz, BetülMohamed, Yehia I.Esmail, AbdullahLu, JianmingMohamed, AmrAzmi, Asfar S.Kaseb, MohamedKasseb, OsamaLi, DanGocio, MichelleKoçak, MehmetSelim, AbdelhafezMa, QingKaseb, Ahmed O.https://hdl.handle.net/20.500.12511/123402024-03-08T10:20:41Z2024-01-01T00:00:00ZIndividual ingredients of NP-101 (Thymoquinone formula) inhibit SARS-CoV-2 pseudovirus infection
Maen, Abdelrahim; Gök Yavuz, Betül; Mohamed, Yehia I.; Esmail, Abdullah; Lu, Jianming; Mohamed, Amr; Azmi, Asfar S.; Kaseb, Mohamed; Kasseb, Osama; Li, Dan; Gocio, Michelle; Koçak, Mehmet; Selim, Abdelhafez; Ma, Qing; Kaseb, Ahmed O.
Thymoquinone TQ, an active ingredient of Nigella Sativa, has been shown to inhibit COVID-19 symptoms in clinical trials. Thymoquinone Formulation (TQF or NP-101) is developed as a novel enteric-coated medication derivative from Nigella Sativa. TQF consists of TQ with a favorable concentration and fatty acids, including palmitic, oleic, and linoleic acids. In this study, we aimed to investigate the roles of individual ingredients of TQF on infection of SARS-CoV-2 variants in-vitro, by utilizing Murine Leukemia Virus (MLV) based pseudovirus particles. We demonstrated that NP-101, TQ, and other individual ingredients, including oleic, linoleic, and palmitic acids inhibited SARS-CoV-2 infection in the MLV-based pseudovirus model. A large, randomized phase 2 study of NP-101 is planned in outpatient COVID-19 patients.
2024-01-01T00:00:00ZDrug utilization studies in Turkiye: A systematic reviewAkıcı, AhmetHavyarimana, DieudonnéDirenç, ErtanAydın, Volkanhttps://hdl.handle.net/20.500.12511/123232024-02-29T07:30:41Z2024-01-01T00:00:00ZDrug utilization studies in Turkiye: A systematic review
Akıcı, Ahmet; Havyarimana, Dieudonné; Direnç, Ertan; Aydın, Volkan
OBJECTIVE: Drug utilization studies (DUS) provide a framework for drug utilization at the national or targeted population level and important information on unmet medical needs, particularly in assessing the rationality of drug use. We aimed to systematically review DUS conducted in Turkiye. METHODS: We examined 162 DUS with an accessible full-text, published as “research articles” and conducted in Turkiye between 2000 and 2021 using medical records and prescription data. We included English or Turkish papers with English abstracts. We examined the scientific characteristics of the publications, source of the data, place/time of collection, research designs, and studied drug groups. RESULTS: We found that 79.6% of articles were in English, 45.1% were listed in SCI/SCIE, and 63.0% were on the WOS platform with 3.5 (interquartile range: 1–15) citations. The mean study period and publication time were 2.9±3.1 and 2.9±2.1 years, respectively. The highest number of studies (17.9%) were published in 2021 and (26.5%) were conducted nationwide. We identified that 93.8% of the studies had retrospective design, 67.8% were conducted in secondary/tertiary health-care institutions, and 54.9% used direct hospital data. We detected that 68.5% of the studies were conducted on the general population, 19.1% on adults, 12.4% on children, and 44.4% were antibiotic oriented. CONCLUSION: Our study showed that a significant portion of the DUS, the trend of which has gained momentum in recent years, was antibiotic focused and conducted with a retrospective design from hospital-based data collected on the general patient population. This situation points to the necessity of expanding the existing DUS range by effectively using the new advantages provided by medical record databases and conducting more DUS that can provide critical clues for specific patients and drug groups.
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