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The therapeutic role of minocycline in Parkinson's disease

Çankaya, Şeyda; Çankaya, Barış; Kılıç, Ülkan; Kılıç, Ertuğrul; Yuluǧ, Burak (Bioexcel Publishing LTD, 2019)

Minocycline, a semisynthetic tetracycline-derived antibiotic, has been shown to exert anti-apoptotic, anti-inflammatory, and antioxidant effects. Furthermore, there is rapidly growing evidence suggesting that minocycline ...

Evidence that melatonin downregulates Nedd4-1 E3 ligase and its role in cellular survival

Yalçın, Esra; Beker, Mustafa Çağlar; Türkseven, Şeyma; Çağlayan, Berrak; Gürel, Büşra; Kılıç, Ülkan; Çağlayan, Ahmet Burak; Kalkan, Rabia; Baykal, Ahmet Tarık; Keleştemur, Taha; Kılıç, Ertuğrul (Academic Press Inc Elsevier Science, 2019)

Indolamine melatonin structurally resembles non-covalent proteasome inhibitors; however, the role of ubiquitin proteasome system (UPS) in neuronal survival and how melatonin carries out UPS inhibition remain largely unknown. ...

A different view on the platelet aggregation inhibitor clopidogrel - a well-suitable anti-oedema agent in a preclinical model of brain injury?

Günal, Mehmet Yalçın; Yuluğ, Burak; Çağlayan, Berrak; Ozansoy, Mehmet; Kılıç, Ülkan; Keskin, İlknur; Kılıç, Ertuğrul (Czech Medical Soc, 2019)

Aim: The neuroprotective effects of clopidogrel have already been shown in various experimental models. Taking into account the fact that clopidogrel is well tolerated and approved for use in various clinical settings, it ...

Interaction of melatonin and Bmal1 in the regulation of PI3K/AKT pathway components and cellular survival

Beker, Mustafa Çağlar; Çağlayan, Berrak; Çağlayan, Ahmet Burak; Kelestemur, Taha; Yalçın, Esra; Çağlayan, Aysun; Kılıç, Ülkan; Baykal, Ahmet Tarık; Reiter, Russel J.; Kılıç, Ertuğrul (Nature Publishing Group, 2019)

The circadian rhythm is driven by a master clock within the suprachiasmatic nucleus which regulates the rhythmic secretion of melatonin. Bmal1 coordinates the rhythmic expression of transcriptome and regulates biological ...

Dose-dependent effects of vitamin 1,25(OH)2D3 on oxidative stress and apoptosis

Çakıcı, Çağrı; Yiğitbaşı, Türkan; Ayla, Şule; Karimkhani, Hadi; Bayramoğlu, Feyza; Yiğit, Pakize; Kılıç, Ertuğrul; Emekli, Nesrin (Walter de Gruyter GmbH, 2018)

The purpose of this study is to examine the dose-dependent effects of vitamin 1,25(OH)2D3 on apoptosis and oxidative stress. In this study, 50 male Balb/c mice were used as control and experiment groups. The mice were ...

Sodium pentaborate pentahydrate and pluronic containing hydrogel increases cutaneous wound healing in vitro and in vivo

Doǧan, Ayşegül; Demirci, Selami; Çağlayan, Ahmet Burak; Kılıç, Ertuğrul; Günal, Mehmet Yalçın; Uslu, Ünal; Cumbul, Alev; Şahin, Fikrettin (Humana Press, 2014)

After a disruption of skin integrity, the body produces an immediate response followed by a functional and comparable regeneration period, referred to as wound healing. Although normal wounds do not need much attention ...

HMG-CoA reductase inhibition promotes stroke recovery perilesional tissue remodeling and contralesional pyramidal tract plasticity

Kılıç, Ertuğrul; Reitmeir, Raluca; Kılıç, Ülkan; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Ethemoğlu, Sinem; Hermann, Dirk M. (Springer Heidelberg, 2014)

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Investigation the effects of memantin and melatonin treatment after traumatic brain injury in mice

Keleştemur, Taha; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Kılıç, Ülkan; Kılıç, Ertuğrul (Springer Heidelberg, 2014)

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The phosphatidylinositol-3 kinase/Akt pathway mediates melatonin's neuroprotective activity after focal cerebral ischemia

Beker, Mustafa Çağlar; Çağlayan, Ahmet Burak; Kılıç, Ertuğrul; Kılıç, Ülkan (Springer Heidelberg, 2014)

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The anxiolytic effects of testosterone may be modulated by central nervous system androgen receptor activity in gonadectomized male mice

Şerefoğlu, Ege Can; Çelik, Duygu Sultan; Çolakerol, Aykut; Yılmaz, Bayram; Kılıç, Ertuğrul; Semerciöz, Atilla (Wiley, 2017)

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