Browsing by Author "Yozgat, Yasemin"
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Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor
Bosbach, Benedikt; Rossi, Ferdinand; Yozgat, Yasemin; Loo, Jennifer; Zhang, Jennifer Q.; Berrozpe, Georgina; Warpinski, Katherine; Ehlers, Imke; Veach, Darren; Kwok, Andrew; Manova, Katia; Antonescu, Cristina R.; DeMatteo, Ronald P.; Besmer, Peter (National Academy of Sciences, 2017)Gastrointestinal stromal tumors (GISTs) predominantly harbor activating mutations in the receptor tyrosine kinase KIT. To genetically dissect in vivo the requirement of different signal transduction pathways emanating from ... -
Evaluation of cardiac arrhythmias by electrocardiographic markers in pediatric patients who have tuberous sclerosis without cardiac rhabdomyoma
Yozgat, Yasemin; Kuş, Hazar Doğuş; Kahraman, Fatma; Elagöz Yüksel, Mine; Fırat, Cem Koray; Toprak, Atakan; Yozgat, Can Yılmaz; Yakut, Kadriye; Sönmez Şahin, Şeyma; İşcan, Akın; Otçu Temur, Hafize; Ergör, Serap Nur; Erenberk, Ufuk; Sarıtaş, Tuba Berra (Elsevier France-Editions Scientifiques Medicales Elsevier, 2021)Background: Tuberous sclerosis (TS) is an autosomal dominant and hereditary disorder. Cardiac rhabdomyoma and arrhythmias are the most deleterious risk factors linked to TS. Although arrhythmias in pediatric patients with ... -
N-acetylcysteine suppresses colistimethate sodium-induced nephrotoxicity via activation of SOD2, eNOS, and MMP3 protein expressions
Ceylan, Bahadır; Ozansoy, Mehmet; Kılıç, Ülkan; Yozgat, Yasemin; Ercan, Çilem; Yıldız, Pelin; Aslan, Turan (Taylor & Francis Ltd., 2018)Objective: To investigate the molecular mechanisms of colistimethate sodium-induced nephrotoxicity and the protective effect of N-acetylcysteine (NAC) against nephrotoxicity.Methods: Twenty-eight Wistar rats were divided ... -
Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice
Sakul, Arzu; Ozansoy, Mehmet; Elibol, Birsen; Ayla, Şule; Günal, Mehmet Yalçın; Yozgat, Yasemin; Basağa, Hüveyda; Şahin, Kazım; Kazancıoğlu, Rümeyza; Kılıç, Ulkan (Tubitak Scientific & Technical Research Council Turkey, 2019)The clinical use of cisplatin, which is a first-line anticancer agent, is highly restricted due to its adverse effects on kidneys that lead to nephrotoxicity. Therefore, some potential reno-protective substances have been ...
