Browsing by Author "Yiğitbaşı, Türkan"
Now showing items 1-20 of 39
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1,25(OH)2D3 vitaminin apopitoz ve oksidatif stres üzerine doza bağlı etkileri
Çakıcı, Çağrı (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2016)Bu çalışmanın amacı1,25(OH)2D3 vitamininin apopitoz ve oksidatif stres üzerine doza bağlı etkilerini araştırmaktır. İstanbul Medipol Üniversitesi Rejeneratif ve Restoratif Tıp Araştırmaları Merkezinde (REMER) yapılan ... -
Association of ischemia-modified albumin with oxidative stress status and insulin resistance in obese patients
Yiğitbaşı, Türkan; Baskın, Yasemin; Akgöl, Evren; Çalıbaşı Koçal, Gizem; Ellidokuz, Hülya (University Press, 2017)Objectives: Obesity is associated with oxidative stress due to the overproduction of free radicals in some accompanying states, such as hyperglycemia, elevated lipid levels and chronic inflammation. Free radical accumulation ... -
Bisphenol a and di(2-ethylhexyl) phthalate exert divergent effects on apoptosis and the Wnt/-catenin pathway in zebrafish embryos: A possible mechanism of endocrine disrupting chemical action
Üstündağ, Ünsal Veli; Ünal, İsmail; Ateş, Perihan Seda; Alturfan, Ahmet Ata; Yiğitbaşı, Türkan; Emekli Alturfan, Ebru (Sage Publications Inc, 2017)Polyethylene terephthalate (PET) and polycarbonate (PC) are the most commonly used plastics in water bottles. Di(2-ethylhexyl) phthalate (DEHP) is used as a plasticizer in PET plastics, and bisphenol A (BPA) is used to ... -
Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines
Pakdemirli, Ahu; Karaca, Caner; Sever, Tolga; Daskın, Ezgi; Leblebici, Asım; Yiğitbaşı, Türkan; Başbınar, Yasemin (TUBITAK Scientific & Technical Research Council Turkey, 2020)Background/aim: Natural products are popular insights for researchers to investigate promising anti-cancer agents since some of these substances have lesser adverse effects restricting the treatment than traditional ... -
Compliance of medical biochemistry education in medical schools with national core education program 2014
Erdem, Sultan Sibel; Yiğitbaşı, Türkan; Yiğit, Pakize; Emekli, Nesrin (Walter De Gruyter Gmbh, 2019)Background: Medical school curriculums are not standardized in Turkey and around the world, which results in great diversity in education. National Core Education Program (NCEP) has been prepared as a frame program and the ... -
Curcumin effects on cell proliferation, angiogenesis and metastasis in colorectal cancer
Çalıbaşı-Kocal, Gizem; Pakdemirli, Ahu; Bayrak, Serdar; Özüpek, Nazlı Mert; Sever, Tolga; Başbınar, Yasemin; Ellidokuz, Hülya; Yiğitbaşı, Türkan (Zerbinis Publications, 2019)Purpose: Curcumin is a natural phytopolyphenol compound isolated from the root of turmeric (Curcuma longa) and possesses a wide range of biological properties. The purpose of this study was to evaluate the antiproliferative, ... -
Çocukluk çağı aritmilerinde yeni nesil dizileme teknikleri kullanılarak nokta mutasyonların analizi
Çaralan, Erdal Fırat (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2018)Normal kalp ritmindeki bozulmalar Uzun QT, Kısa QT, Brugada, Katekolaminerjik Polimorfik Ventriküler Taşikardi (KPVT) ve Aritmogenik Sağ Ventriküler Taşikardi (ASVT) gibi hastalıklara sebep olmaktadır. Yeni nesil dizileme ... -
Demir eksikliği anemisi olan ve olmayan bireylerde serum sialik asit düzeyleri
Ülfer, Gözde; İstanbullu Tosun, Ayşe; Olmuşçelik, Oktay; Yiğitbaşı, Türkan; Çakıcı, Çağrı; Bayramoğlu, Feyza; Emekli, Nesrin (2017)Amaç: Bu çalışmanın amacı demir eksikliği anemisi (DEA) parametreleri ile serum total sialik asit (SA) değerleri arasındaki ilişkinin incelenmesidir. Yöntemler: Çalışmada DEA olan 30 hasta ve 30 sağlıklı kişide serum total ... -
Deneysel prostat kanserinde tümör metabolizmasının laktat dehidrojenaz ilişkili değişiminin apoptoz ve epitelyal mezenkimal dönüşüm (EMT) üzerindeki rolü
Çakıcı, Çağrı (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2021)Çalışmamızda oluşturulan deneysel prostat kanser modelinde LHD-A inhibitörünün 1,25(OH)2D3 vitamini ve Dosetaksel ile kombinasyonunun apoptoz, oksidatif stres ve EMT mekanizmaları üzerine etkilerinin araştırılması ... -
Dose-dependent effects of vitamin 1,25(OH)2D3 on oxidative stress and apoptosis
Çakıcı, Çağrı; Yiğitbaşı, Türkan; Ayla, Şule; Karimkhani, Hadi; Bayramoğlu, Feyza; Yiğit, Pakize; Kılıç, Ertuğrul; Emekli, Nesrin (Walter de Gruyter GmbH, 2018)The purpose of this study is to examine the dose-dependent effects of vitamin 1,25(OH)2D3 on apoptosis and oxidative stress. In this study, 50 male Balb/c mice were used as control and experiment groups. The mice were ... -
Effects of water samples in polyethylene terephthalate bottles stored at different conditions on zebrafish embryos with relevance to endocrine disrupting chemical migration and adenomatous polyposis coli tumor suppressor gene
Üstündağ, Ünsal Veli; Ünal, İsmail; Ateş, Perihan Seda; Tırpanç, Aybüke; Eğilmezer, Gizem; Alturfan, Ahmet Ata; Yiğitbaşı, Türkan; Emekli-Alturfan, Ebru (Marmara University, 2019)Objective: Polyethylene terephthalate (PET) is a material that is most commonly used for production of clear plastic bottles. Adenomatous polyposis coli (APC) and beta-catenin have been related with cancer. Aim was to ... -
An efficient biomarker panel for diagnosis of breast cancer using surface-enhanced laser desorption ionization time-of-flight mass spectrometry
Yiğitbaşı, Türkan; Çalıbaşı-Kocal, Gizem; Büyükuslu, Nihal; Atahan, Murat Kemal; Küpeli, Hakan; Yiğit, Seyran; Tarcan, Ercüment; Baskın, Yasemin (Spandidos Publications Ltd, 2018)Breast cancer (BC) is the most frequently diagnosed cancer that affects women worldwide. Early detection of BC is important to improve survival rates and decrease mortality. The aim of the present study was to investigate ... -
Evaluation of satisfaction with over-the-counter weight loss supplements
Majority of studies on satisfaction with medication examine satisfaction with a prescribed pharmaceutical agent, while exploration of satisfaction with over-The-counter drugs is limited. This study aims to examine satisfaction ... -
Evaluation of the interaction between proliferation, oxidant-antioxidant status, Wnt pathway, and apoptosis in zebrafish embryos exposed to silver nanoparticles used in textile industry
Eryılmaz, Oğuz; Ateş, Perihan Seda; Ünal, İsmail; Üstündağ, Ünsal Veli; Bay, Sadık; Alturfan, Ahmet Ata; Yiğitbaşı, Türkan; Emekli Alturfan, Ebru; Akalın, Mehmet (Wiley, 2018)Antimicrobial textile products are developing rapidly as an important part of functional textiles. Silver nanoparticles (AgNPs) are nanotechnology products with antimicrobial properties. However, exposure to nanoparticles ... -
HPLC floresan dedektör kullanılarak poliaminlerin serumda saptanması için metot geliştirme ve validasyonlarının yapılması
Çakan, Orhan (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2018)Poliaminlerin canlı organizmalarda büyüme faktörü olarak ve metabolik olayları düzenlemede önemli görevleri vardır. Doğal poliaminler; putresin, spermidin ve spermin tüm canlı hücrelerde bulunur. Poliaminlerin ölçümü, ... -
Ischemia-modified albumin levels in patients with idiopathic sudden sensorineural hearing loss
Objectives: This study aims to investigate whether serum levels of ischemia-modified albumin (IMA) are associated with idiopathic sudden sensorineural hearing loss (ISSNHL). Patients and Methods: Between December 2015 and ... -
Kolorektal kanserde tümör metabolizmasının laktat dehidrogenaz bağlantılı modifikasyonunun kemoterapi etkinliği üzerindeki rolü
Çalıbaşı Koçal, Gizem (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2019)Kanser hücreleri, Warburg etkisi olarak bilinen durum altında proliferasyonlarını ve büyümelerini desteklemek için metabolizmalarını yeniden programlayarak oksidatif fosforilasyon yerine, pirüvat üzerinden laktat oluşumunu ... -
Leptin in sperm analysis can be a new indicator
Önel, Tuğçe; Ayla, Şule; Keskin, İlknur; Parlayan, Cüneyd; Yiğitbaşı, Türkan; Kolbaşı, Bircan; Varlı Yelke, Tuba; Şenel Ustabaş, Tuğba (Elsevier GMBH, 2019)Purpose Radiotherapy, chemotherapy, various tumors and invasive surgery can result in ejaculatory dysfunction and testicular insufficiency. Sperm cryopreservation is the only method which can provide a baby for couples. ... -
Limitations of cross-talk between osteosarcoma and bone marrow-derived mesenchymal stem cells
Başbınar, Yasemin; Uysal, Tuğba; Karaca, Caner; Daşkın, Ezgi; Meco, Hanife Ecenur; Pakdemirli, Ahu; Yiğitbaşı, Türkan; Ellidokuz, Hülya (Aves Press Ltd., 2019)Objectives: Metastasis is a multi-step process which leads the tumor cells to escape from primer tumor region due to their need to gain malign phenotypes. While the effect of bone marrow-derived mesenchymal stem cells upon ... -
Methylparaben induces malformations and alterations on apoptosis, oxidant-antioxidant status, ccnd1 and myca expressions in zebrafish embryos
Ateş, Perihan Seda; Ünal, İsmail; Üstündağ, Ünsal Veli; Alturfan, Ahmet Ata; Yiğitbaşı, Türkan; Emekli Alturfan, Ebru (Wiley, 2018)Methylparabens (MP) are widely used as preservatives in cosmetics, pharmacy, and food industry. Although acute toxicity studies in animals indicated that parabens are not significantly toxic, the effects of chronic exposure ...
