Browsing by Author "Yiğitbaşı, Türkan"
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1,25(OH)2D3 vitaminin apopitoz ve oksidatif stres üzerine doza bağlı etkileri
Çakıcı, Çağrı (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2016)Bu çalışmanın amacı1,25(OH)2D3 vitamininin apopitoz ve oksidatif stres üzerine doza bağlı etkilerini araştırmaktır. İstanbul Medipol Üniversitesi Rejeneratif ve Restoratif Tıp Araştırmaları Merkezinde (REMER) yapılan ... -
Association of ischemia-modified albumin with oxidative stress status and insulin resistance in obese patients
Yiğitbaşı, Türkan; Baskın, Yasemin; Akgöl, Evren; Çalıbaşı Koçal, Gizem; Ellidokuz, Hülya (University Press, 2017)Objectives: Obesity is associated with oxidative stress due to the overproduction of free radicals in some accompanying states, such as hyperglycemia, elevated lipid levels and chronic inflammation. Free radical accumulation ... -
Bisphenol a and di(2-ethylhexyl) phthalate exert divergent effects on apoptosis and the Wnt/-catenin pathway in zebrafish embryos: A possible mechanism of endocrine disrupting chemical action
Üstündağ, Ünsal Veli; Ünal, İsmail; Ateş, Perihan Seda; Alturfan, Ahmet Ata; Yiğitbaşı, Türkan; Emekli Alturfan, Ebru (Sage Publications Inc, 2017)Polyethylene terephthalate (PET) and polycarbonate (PC) are the most commonly used plastics in water bottles. Di(2-ethylhexyl) phthalate (DEHP) is used as a plasticizer in PET plastics, and bisphenol A (BPA) is used to ... -
Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines
Pakdemirli, Ahu; Karaca, Caner; Sever, Tolga; Daskın, Ezgi; Leblebici, Asım; Yiğitbaşı, Türkan; Başbınar, Yasemin (TUBITAK Scientific & Technical Research Council Turkey, 2020)Background/aim: Natural products are popular insights for researchers to investigate promising anti-cancer agents since some of these substances have lesser adverse effects restricting the treatment than traditional ... -
Comparison of the effects of clinical observation and protocol-based weaning on antioxidant stress factors
Erdoğan, Cem; Kızılaslan, Deniz; Tunay, Burcu; Karaaslan, Pelin; Ülfer, Gözde; Yiğitbaşı, Türkan; Demiraran, Yavuz; Öz, Hüseyin (NLM (Medline), 2022)BACKGROUND: We aimed to compare the effects of observation of the physician (POB) or by adhering to the protocol-based (PB) weaning methods on total antioxidant capacity (TAC) and total oxidative stress (TOS) levels and ... -
Compliance of medical biochemistry education in medical schools with national core education program 2014
Erdem, Sultan Sibel; Yiğitbaşı, Türkan; Yiğit, Pakize; Emekli, Nesrin (Walter De Gruyter Gmbh, 2019)Background: Medical school curriculums are not standardized in Turkey and around the world, which results in great diversity in education. National Core Education Program (NCEP) has been prepared as a frame program and the ... -
Could the increase in oxidative stress be the reason for the increased polyamine levels in diabetic obese and non-diabetic obese patients?
Göktürk, Nurcan; Şahin, Hicret; Bayramoğlu, Feyza; Çakıcı, Çağrı; Büyükuslu, Nihal; Yiğit, Pakize; Yiğitbaşı, Türkan (İstanbul Medipol University, 2022)Putresin, spermine, and spermidine are important polyamines found in all living organisms. In this study, as a first in the literature, we aimed to investigate polyamines levels and their relationship with oxidative stress ... -
COVID-19 pozitif hastalarda SARS-CoV-2 varyantlarının prevalansı
Aydoğan, Okan; Gözün Şaylan, Ezgi; Güven, Özlem; Ayaz, Akif; Yiğitbaşı, Türkan (DOC Design and Informatics Co. Ltd., 2022)Amaç: Dünya Sağlık Örgütü (DSÖ) tarafından alfa (B.1.1.7), beta (B.1.351), gamma (P.1), delta (B.1.617.2) ve omic - ron (B.1.1.529) endişe verici varyantlar (“variants of concern – VOCs”) olarak sınıflandırılmıştır. ... -
The creation of unilateral intermittent and unintermittent renal ischemia-reperfusion models in rats
Soytaş, Mustafa; Gürsoy, Duygu; Boz, Mustafa Yücel; Çakıcı, Çağrı; Keskin, İlknur; Yiğitbaşı, Türkan; Güven, Selçuk; Horuz, Rahim; Albayrak, Selami (Wolters Kluwer Medknow Publications, 2021)Background and Aim: This study aims to establish unilateral intermittent and unintermittent partial nephrectomy-like renal ischemia-reperfusion (I-R) model in rats and to compare the results with biochemical findings. ... -
Curcumin effects on cell proliferation, angiogenesis and metastasis in colorectal cancer
Çalıbaşı-Kocal, Gizem; Pakdemirli, Ahu; Bayrak, Serdar; Özüpek, Nazlı Mert; Sever, Tolga; Başbınar, Yasemin; Ellidokuz, Hülya; Yiğitbaşı, Türkan (Zerbinis Publications, 2019)Purpose: Curcumin is a natural phytopolyphenol compound isolated from the root of turmeric (Curcuma longa) and possesses a wide range of biological properties. The purpose of this study was to evaluate the antiproliferative, ... -
Çocukluk çağı aritmilerinde yeni nesil dizileme teknikleri kullanılarak nokta mutasyonların analizi
Çaralan, Erdal Fırat (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2018)Normal kalp ritmindeki bozulmalar Uzun QT, Kısa QT, Brugada, Katekolaminerjik Polimorfik Ventriküler Taşikardi (KPVT) ve Aritmogenik Sağ Ventriküler Taşikardi (ASVT) gibi hastalıklara sebep olmaktadır. Yeni nesil dizileme ... -
Demir eksikliği anemisi olan ve olmayan bireylerde serum sialik asit düzeyleri
Ülfer, Gözde; İstanbullu Tosun, Ayşe; Olmuşçelik, Oktay; Yiğitbaşı, Türkan; Çakıcı, Çağrı; Bayramoğlu, Feyza; Emekli, Nesrin (2017)Amaç: Bu çalışmanın amacı demir eksikliği anemisi (DEA) parametreleri ile serum total sialik asit (SA) değerleri arasındaki ilişkinin incelenmesidir. Yöntemler: Çalışmada DEA olan 30 hasta ve 30 sağlıklı kişide serum total ... -
Deneysel prostat kanserinde tümör metabolizmasının laktat dehidrojenaz ilişkili değişiminin apoptoz ve epitelyal mezenkimal dönüşüm (EMT) üzerindeki rolü
Çakıcı, Çağrı (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2021)Çalışmamızda oluşturulan deneysel prostat kanser modelinde LHD-A inhibitörünün 1,25(OH)2D3 vitamini ve Dosetaksel ile kombinasyonunun apoptoz, oksidatif stres ve EMT mekanizmaları üzerine etkilerinin araştırılması ... -
Dose-dependent effects of vitamin 1,25(OH)2D3 on oxidative stress and apoptosis
Çakıcı, Çağrı; Yiğitbaşı, Türkan; Ayla, Şule; Karimkhani, Hadi; Bayramoğlu, Feyza; Yiğit, Pakize; Kılıç, Ertuğrul; Emekli, Nesrin (Walter de Gruyter GmbH, 2018)The purpose of this study is to examine the dose-dependent effects of vitamin 1,25(OH)2D3 on apoptosis and oxidative stress. In this study, 50 male Balb/c mice were used as control and experiment groups. The mice were ... -
Effects of water samples in polyethylene terephthalate bottles stored at different conditions on zebrafish embryos with relevance to endocrine disrupting chemical migration and adenomatous polyposis coli tumor suppressor gene
Üstündağ, Ünsal Veli; Ünal, İsmail; Ateş, Perihan Seda; Tırpanç, Aybüke; Eğilmezer, Gizem; Alturfan, Ahmet Ata; Yiğitbaşı, Türkan; Emekli-Alturfan, Ebru (Marmara University, 2019)Objective: Polyethylene terephthalate (PET) is a material that is most commonly used for production of clear plastic bottles. Adenomatous polyposis coli (APC) and beta-catenin have been related with cancer. Aim was to ... -
An efficient biomarker panel for diagnosis of breast cancer using surface-enhanced laser desorption ionization time-of-flight mass spectrometry
Yiğitbaşı, Türkan; Çalıbaşı-Kocal, Gizem; Büyükuslu, Nihal; Atahan, Murat Kemal; Küpeli, Hakan; Yiğit, Seyran; Tarcan, Ercüment; Baskın, Yasemin (Spandidos Publications Ltd, 2018)Breast cancer (BC) is the most frequently diagnosed cancer that affects women worldwide. Early detection of BC is important to improve survival rates and decrease mortality. The aim of the present study was to investigate ... -
Evaluation of satisfaction with over-the-counter weight loss supplements
Majority of studies on satisfaction with medication examine satisfaction with a prescribed pharmaceutical agent, while exploration of satisfaction with over-The-counter drugs is limited. This study aims to examine satisfaction ... -
Evaluation of the interaction between proliferation, oxidant-antioxidant status, Wnt pathway, and apoptosis in zebrafish embryos exposed to silver nanoparticles used in textile industry
Eryılmaz, Oğuz; Ateş, Perihan Seda; Ünal, İsmail; Üstündağ, Ünsal Veli; Bay, Sadık; Alturfan, Ahmet Ata; Yiğitbaşı, Türkan; Emekli Alturfan, Ebru; Akalın, Mehmet (Wiley, 2018)Antimicrobial textile products are developing rapidly as an important part of functional textiles. Silver nanoparticles (AgNPs) are nanotechnology products with antimicrobial properties. However, exposure to nanoparticles ... -
Farede prematüre over yetmezliğinde mTERT telomeraz katalitik alt ünitesinin rolünün belirlenmesi
Memelilerde prenatal hayatta oluşan oosit rezervi, postnatal hayatta azalarak tükenmektedir. Foliküler atrezi olarak adlandırılan bu mekanizma ile ovariyal yaşlanma meydana gelmektedir. Primordiyal folikül havuzu tekrardan ... -
HPLC floresan dedektör kullanılarak poliaminlerin serumda saptanması için metot geliştirme ve validasyonlarının yapılması
Çakan, Orhan (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2018)Poliaminlerin canlı organizmalarda büyüme faktörü olarak ve metabolik olayları düzenlemede önemli görevleri vardır. Doğal poliaminler; putresin, spermidin ve spermin tüm canlı hücrelerde bulunur. Poliaminlerin ölçümü, ...
