Browsing by Author "Yalçın, Esra"
Now showing items 1-20 of 21
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Acute and post-acute neuromodulation induces stroke recovery by promoting survival signaling, neurogenesis, and pyramidal tract plasticity
Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Çağlayan, Berrak; Yalçın, Esra; Çağlayan, Aysun; Yuluğ, Burak; Hanoğlu, Lütfü; Kutlu, Selim; Doeppner, Thorsten Roland; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Frontiers Media Sa, 2019)Repetitive transcranial magnetic stimulation (rTMS) has gained interest as a non-invasive treatment for stroke based on the data promoting its effects on functional recovery. However, the exact action mechanisms by which ... -
Effects of neurotrophic factors cdnf and manf on brain plasticity and repair after brain ischemia
Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Çağlayan, Berrak; Altunay, Serdar; Dalay, Arman; Dilden, Aysun; Sertel, Elif; Keleştemur, Taha; Yalçın, Esra; Kılıç, Ülkan; Saarma, Mart; Kılıç, Ertuğrul (Wiley-Blackwell, 2016)... -
Effects of normobaric oxygen and melatonin on reperfusion injury: Role of cerebral microcirculation
Beker, Mustafa; Çağlayan, Ahmet Burak; Keleştemur, Taha; Çaǧlayan, Berrak; Yalçın, Esra; Yuluǧ, Burak; Kılıç, Ülkan; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Impact Journals, 2015)In order to protect the brain before an irreversible injury occurs, penumbral oxygenation is the primary goal of current acute ischemic stroke treatment. However, hyperoxia treatment remains controversial due to the risk ... -
Evidence that activation of P2X7R does not exacerbate neuronal death after optic nerve transection and focal cerebral ischemia in mice
Çağlayan, Berrak; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Yalçın, Esra; Beker, Merve; Keleştemur, Taha; Sertel, Elif; Öztürk, Gürkan; Kılıç, Ülkan; Şahin, Fikrettin; Kılıç, Ertuğrul (Academic Press Inc Elsevier Science, 2017)Conflicting data in the literature about the function of P2X7R in survival following ischemia necessitates the conductance of in-depth studies. To investigate the impacts of activation vs inhibition of the receptor on ... -
Evidence that melatonin downregulates Nedd4-1 E3 ligase and its role in cellular survival
Yalçın, Esra; Beker, Mustafa Çağlar; Türkseven, Şeyma; Çağlayan, Berrak; Gürel, Büşra; Kılıç, Ülkan; Çağlayan, Ahmet Burak; Kalkan, Rabia; Baykal, Ahmet Tarık; Keleştemur, Taha; Kılıç, Ertuğrul (Academic Press Inc Elsevier Science, 2019)Indolamine melatonin structurally resembles non-covalent proteasome inhibitors; however, the role of ubiquitin proteasome system (UPS) in neuronal survival and how melatonin carries out UPS inhibition remain largely unknown. ... -
Interaction of melatonin and Bmal1 in the regulation of PI3K/AKT pathway components and cellular survival
Beker, Mustafa Çağlar; Çağlayan, Berrak; Çağlayan, Ahmet Burak; Kelestemur, Taha; Yalçın, Esra; Çağlayan, Aysun; Kılıç, Ülkan; Baykal, Ahmet Tarık; Reiter, Russel J.; Kılıç, Ertuğrul (Nature Publishing Group, 2019)The circadian rhythm is driven by a master clock within the suprachiasmatic nucleus which regulates the rhythmic secretion of melatonin. Bmal1 coordinates the rhythmic expression of transcriptome and regulates biological ... -
Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice
Kılıç, Ülkan; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Günal, Mehmet Yalçın; Çağlayan, Berrak; Yalçın, Esra; Keleştemur, Taha; Gündoğdu, Reyhan Zeynep; Yuluğ, Burak; Yılmaz, Bayram; Kerman, Bilal Ersen; Kılıç, Ertuğrul (Elsevier Sciences Bv, 2017)Apart from its potent antioxidant property, recent studies have revealed that melatonin promotes PI3K/Akt phosphorylation following focal cerebral ischemia (FCI) in mice. However, it is not clear (i) whether increased ... -
The role of repetative transcranial magnetic stimulation after focal cerebral ischemia
Çağlayan, Ahmet Burak; Yalçın, Esra; Altunay, Serdar; Sertel, Elif; Dilden, Aysun; Karaçay, Reyda; Beker, Mustafa Çağlar; Keleştemur, Taha; Çağlayan, Berrak; Kutlu, Selim; Kılıç, Ülkan; Kılıç, Ertuğrul (Wiley, 2017)... -
Short-term diet restriction but not alternate day fasting prevents cisplatin-induced nephrotoxicity in mice
Günebakan, Evrin; Yalçın, Esra; Çikler Dülger, Esra; Yiğitbaşı, Ahmet; Ateş, Nilay; Çağlayan, Aysun; Beker, Mustafa Çağlar; Şahin, Kâzim; Korkaya, Hasan; Kılıç, Ertuğrul (MDPI AG, 2020)Cisplatin (CP) is one of the most preferred platinum-containing antineoplastic drugs. However, even in nontoxic plasma concentrations, it may cause kidney injury. To be able to increase its effective pharmacological dose, ... -
Solüt taşıyıcıların beyin hasarı farkmakoterapisindeki rolü
Yalçın, Esra (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2017)İlaç birikimi olarak ifade edilen farmasötik ajanların beyine girişi ve belirli konsantrasyon seviyelerine ulaşmaları, hem pasif hem de kan beyin bariyeri (KBB) boyunca bulunan aktif taşıyıcılar tarafından düzenlenen bir ... -
Targeting different pathophysiological events after traumatic brain injury in mice: Role of melatonin and memantine
Keleştemur, Taha; Yuluğ, Burak; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Kılıç, Ülkan; Çağlayan, Berrak; Yalçın, Esra; Gündoğdu, Reyhan Zeynep; Kılıç, Ertuğrul (Elsevier Ireland Ltd, 2016)The tissue damage that emerges during traumatic brain injury (TBI) is a consequence of a variety of pathophysiological events, including free radical generation and over-activation of N-methyl-D-aspartate-type glutamate ...
